Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | KARS1 | Q15046 | 3/20 | 0.58 |
| ▸ | SOD1 | P00441 | 1/20 | 0.58 |
| ▸ | RXRA | P19793 | 1/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | RXRB | P28702 | 1/20 | 0.58 |
| ▸ | RXRG | P48443 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.52 |
| ▸ | POLA1 | P09884 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24591878 | 0.91 | LMNA (0.65) | CYP3A4LMNAKARS1SOD1RXRA | |
| SCHEMBL2994458 | 0.88 | SOD1 (0.75) | CYP3A4LMNAKARS1SOD1RXRA | |
| SCHEMBL2991215 | 0.88 | LMNA (0.73) | CYP3A4LMNAKARS1SOD1RXRA | |
| SCHEMBL2985207 | 0.87 | LMNA (0.72) | CYP3A4LMNAKARS1SOD1RXRA | |
| SCHEMBL2990676 | 0.86 | CYP3A4 (0.71) | CYP3A4LMNAKARS1SOD1RXRA | |
| SCHEMBL2993685 | 0.86 | LMNA (0.71) | CYP3A4LMNAKARS1SOD1RXRA | |
| SCHEMBL2980020 | 0.86 | LMNA (0.71) | CYP3A4LMNAKARS1SOD1RXRA | |
| SCHEMBL2989705 | 0.85 | CYP3A4 (1.00) | CYP3A4LMNAKARS1RXRACCNE1 | |
| SCHEMBL13208224 | 0.85 | LMNA (0.69) | CYP3A4LMNAKARS1SOD1RXRA | |
| SCHEMBL3462324 | 0.85 | CYP3A4 (1.00) | CYP3A4LMNAKARS1RXRACCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776558-B2 | Human G protein-coupled receptor and modulators thereof for the treatment of cell death-related disorders | ARENA PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20080125491-A1 | Human G Protein-Coupled Receptor and Modulators Thereof for the Treatment of Cell Death-Related Disorders | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125491-A1 | Human G Protein-Coupled Receptor and Modulators Thereof for the Treatment of Cell Death-Related Disorders | GPR65, GPR3, GPR52 | CYP3A4 4826/4885LMNA 1175/4885KARS1 4363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.