Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | TNNI3 | P19429 | 2/20 | 0.52 |
| ▸ | TNNT2 | P45379 | 2/20 | 0.52 |
| ▸ | TNNC1 | P63316 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | IDE | P14735 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CYBB | P04839 | 2/20 | 0.51 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13779295 | 0.84 | PDE4B (0.58) | PDE4BALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL12110587 | 0.81 | DNM1 (0.61) | PDE4BALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6879860 | 0.79 | MAP3K5 (0.51) | ALDH1A1MEN1KMT2AMAPTTNNI3 | |
| SCHEMBL6879856 | 0.79 | MAP3K5 (0.51) | ALDH1A1MEN1KMT2AMAPTTNNI3 | |
| SCHEMBL13726902 | 0.75 | PDE4B (0.58) | PDE4BALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL13726901 | 0.75 | PDE4B (0.58) | PDE4BALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL18103095 | 0.75 | MEN1 (0.72) | PDE4BALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL12655513 | 0.74 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AMAPTTNNI3 | |
| SCHEMBL14777217 | 0.73 | PDE4B (0.76) | PDE4BALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14777216 | 0.73 | PDE4B (0.76) | PDE4BALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190832-A1 | Mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and structural templates | NATIONAL INSTITUTE OF IMMUNOLOGY. | 2010-07-29 | — | — | US | disclosed |
| US-20100190832-A1 | Mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and structural templates | NATIONAL INSTITUTE OF IMMUNOLOGY. | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190832-A1 | Mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and structural templates | TTR, TPR, POT1 | PDE4B 4660/4885ALDH1A1 2468/4885MEN1 3323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.