Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LGMN | Q99538 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2293955 | 0.88 | DDB1 (0.44) | DDB1CRBNSMN1; SMN2LMNANPC1 | |
| SCHEMBL13651747 | 0.79 | DDB1 (0.39) | DDB1CRBNSMN1; SMN2LMNANPC1 | |
| SCHEMBL27299225 | 0.77 | DDB1 (0.43) | DDB1CRBNSMN1; SMN2LMNANPC1 | |
| SCHEMBL498349 | 0.76 | DDB1 (0.47) | DDB1CRBNSMN1; SMN2LMNANPC1 | |
| SCHEMBL560681 | 0.76 | DDB1 (0.47) | DDB1CRBNSMN1; SMN2LMNANPC1 | |
| SCHEMBL2271664 | 0.75 | AKT1 (0.36) | CTSLCTSBCTSS | |
| SCHEMBL12355229 | 0.70 | DDB1 (0.47) | DDB1CRBNSMN1; SMN2LMNANPC1 | |
| SCHEMBL28436910 | 0.70 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNANPC1RAB9AGAA | |
| SCHEMBL2297578 | 0.69 | DDB1 (0.49) | DDB1CRBNSMN1; SMN2LMNANPC1 | |
| SCHEMBL10611547 | 0.67 | DDB1 (0.62) | DDB1CRBNSMN1; SMN2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389742-B2 | 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylate, process for production of the same, and use of the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-03-05 | — | — | US | claimed |
| US-8003808-B2 | 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylates, process for production of the same, and use of the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-08-23 | — | — | US | claimed |
| US-20110201807-A1 | 3-HYDRAZINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, PROCESS FOR PRODUCTION OF THE SAME, AND USE OF THE SAME | TANAKA DAISUKE | 2011-08-18 | — | — | US | claimed |
| US-20090253917-A1 | 3-HYDRAZINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATES, PROCESS FOR PRODUCTION OF THE SAME, AND USE OF THE SAME | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-10-08 | — | — | US | claimed |
| US-8415487-B2 | Process for preparing (3R)-2′-(4-bromo-2-fluorobenzyl)spiro-[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-A]pyrazine]-1′,2,3′,5(2H′)-tetraone | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-04-09 | — | — | US | disclosed |
| US-8389742-B2 | 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylate, process for production of the same, and use of the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-03-05 | — | — | US | disclosed |
| US-20120010405-A1 | OPTICALLY ACTIVE 3-AMINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, PROCESS FOR PRODUCTION OF THE COMPOUND, AND USE OF THE COMPOUND | TANAKA DAISUKE (JP) | 2012-01-12 | — | — | US | disclosed |
| US-8058456-B2 | Optically active 3-amino-2,5-dioxopyrrolidine-3-carboxylate, process for production of the compound, and use of the compound | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-11-15 | — | — | US | disclosed |
| US-8003808-B2 | 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylates, process for production of the same, and use of the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-08-23 | — | — | US | disclosed |
| US-20110201807-A1 | 3-HYDRAZINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, PROCESS FOR PRODUCTION OF THE SAME, AND USE OF THE SAME | TANAKA DAISUKE | 2011-08-18 | — | — | US | disclosed |
| US-20110190497-A1 | Process for production of 2,5 dioxopyrrolidine 3 carboxylate | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-08-04 | — | — | US | disclosed |
| US-20110190497-A1 | Process for production of 2,5 dioxopyrrolidine 3 carboxylate | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-08-04 | — | — | US | disclosed |
| US-20110190497-A1 | Process for production of 2,5 dioxopyrrolidine 3 carboxylate | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-08-04 | — | — | US | disclosed |
| US-20090286980-A1 | OPTICALLY ACTIVE 3-AMINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, PROCESS FOR PRODUCTION OF THE COMPOUND, AND USE OF THE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-11-19 | — | — | US | disclosed |
| US-20090253917-A1 | 3-HYDRAZINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATES, PROCESS FOR PRODUCTION OF THE SAME, AND USE OF THE SAME | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253917-A1 | 3-HYDRAZINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATES, PROCESS FOR PRODUCTION OF THE SAME, AND USE OF THE SAME | SLC5A1, TERT, CBR3 | DDB1 3636/4885CRBN 3259/4885SMN1; SMN2 3912/4885 |
| US-20110190497-A1 | Process for production of 2,5 dioxopyrrolidine 3 carboxylate | REN, PKD1, KCNT1 | DDB1 3570/4885CRBN 4418/4885SMN1; SMN2 2198/4885 |
| US-20090286980-A1 | OPTICALLY ACTIVE 3-AMINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, PROCESS FOR PRODUCTION OF THE COMPOUND, AND USE OF THE COMPOUND | REN, GPR119, RANBP1 | DDB1 4446/4885CRBN 4856/4885SMN1; SMN2 3700/4885 |
| US-20120010405-A1 | OPTICALLY ACTIVE 3-AMINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, PROCESS FOR PRODUCTION OF THE COMPOUND, AND USE OF THE COMPOUND | REN, GPR119, RANBP1 | DDB1 4446/4885CRBN 4856/4885SMN1; SMN2 3700/4885 |
| US-20110201807-A1 | 3-HYDRAZINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, PROCESS FOR PRODUCTION OF THE SAME, AND USE OF THE SAME | CBR3, TERT, NOX4 | DDB1 3985/4885CRBN 3626/4885SMN1; SMN2 3963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.