Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6371982 | 0.84 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL13256585 | 0.80 | HPGD (0.58) | ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL6372806 | 0.78 | TP53 (0.66) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL17786077 | 0.76 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL7059927 | 0.74 | TP53 (0.76) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL23891117 | 0.73 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL3628079 | 0.73 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL9036669 | 0.72 | TP53 (0.61) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL9566017 | 0.72 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL29822323 | 0.71 | TP53 (0.69) | ALDH1A1HPGDTP53TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288380-B2 | Thiophenediamine derivative having urea structure | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2012-10-16 | — | — | US | disclosed |