Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13257863 | 0.90 | AKT1 (0.37) | DRD2AKT1MEN1KMT2ANAMPT | |
| SCHEMBL13258147 | 0.88 | LMNA (0.41) | DRD2AKT1MEN1KMT2ANAMPT | |
| SCHEMBL3789293 | 0.86 | NAMPT (0.42) | MEN1KMT2ANAMPTSMN1; SMN2ADORA2A | |
| SCHEMBL3795447 | 0.80 | AKT1 (0.43) | DRD2AKT1SLC40A1MEN1KMT2A | |
| SCHEMBL3789575 | 0.77 | ALDH1A1 (0.40) | MEN1KMT2ANAMPT | |
| SCHEMBL3794645 | 0.76 | NAMPT (0.42) | MEN1KMT2ANAMPTSMN1; SMN2HDAC1 | |
| SCHEMBL3797563 | 0.74 | NAMPT (0.43) | MEN1KMT2ANAMPTSMN1; SMN2DGAT2 | |
| SCHEMBL3786760 | 0.72 | EPHX2 (0.48) | HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL3789642 | 0.69 | AKR1B1 (0.39) | — | |
| SCHEMBL1870660 | 0.67 | KMT2A (0.52) | MEN1KMT2ATP53RXFP1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |