Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789293 | 0.90 | NAMPT (0.42) | NAMPTKMT2AMAPTMEN1CSNK1D | |
| SCHEMBL3794645 | 0.86 | NAMPT (0.42) | NAMPTKMT2AMAPTMEN1CSNK1D | |
| SCHEMBL3797563 | 0.84 | NAMPT (0.43) | ALDH1A1NAMPTKMT2AMAPTMEN1 | |
| SCHEMBL3785444 | 0.77 | NAMPT (0.44) | NAMPTKMT2AMAPTMEN1LMNA | |
| SCHEMBL13258013 | 0.77 | DRD2 (0.38) | NAMPTKMT2AMEN1 | |
| SCHEMBL3805799 | 0.73 | DDR1 (0.41) | ALDH1A1KMT2AMAPTMEN1HPGD | |
| SCHEMBL13257863 | 0.72 | AKT1 (0.37) | NAMPTKMT2AMEN1 | |
| SCHEMBL3788876 | 0.72 | RIPK1 (0.38) | — | |
| SCHEMBL3790657 | 0.71 | KMT2A (0.39) | ALDH1A1KMT2AMAPTHTT | |
| SCHEMBL3798917 | 0.71 | EPHX2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |