Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | GCK | P35557 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ATF1 | P18846 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13265940 | 0.85 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2GLAPKMMAPT | |
| SCHEMBL13265974 | 0.78 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2GLAPKMEDNRA | |
| SCHEMBL13265785 | 0.77 | SMN1; SMN2 (0.58) | ALDH1A1SMN1; SMN2GLAGCKMAPK1 | |
| SCHEMBL618503 | 0.75 | SLC6A3 (0.54) | L3MBTL1KMT2AHPGDCYP2C9CYP2C19 | |
| SCHEMBL13265841 | 0.71 | TSHR (0.67) | ALDH1A1SMN1; SMN2MAPK1PKML3MBTL1 | |
| SCHEMBL13265834 | 0.70 | SMN1; SMN2 (0.68) | ALDH1A1SMN1; SMN2ALOX15PKML3MBTL1 | |
| SCHEMBL9625755 | 0.70 | SIRT1 (0.58) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1MAPT | |
| SCHEMBL6630665 | 0.68 | SIRT1 (0.77) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1MAPT | |
| SCHEMBL13265939 | 0.68 | NPC1 (0.65) | ALDH1A1SMN1; SMN2PKML3MBTL1NPC1 | |
| SCHEMBL13265770 | 0.68 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2PKMMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754773-B2 | Composition and synthesis of new reagents for inhibition of HIV replication | UNIVERSITY OF MASSACHUSETTS (US) | 2010-07-13 | — | — | US | disclosed |
| US-20070099919-A1 | Composition and synthesis of new reagents for inhibition of HIV replication | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099919-A1 | Composition and synthesis of new reagents for inhibition of HIV replication | REV1, MAVS, ISG15 | ALDH1A1 4359/4885SMN1; SMN2 4378/4885GLA 4106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.