Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CTSV | O60911 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13265974 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1GLAKMT2AMEN1 | |
| SCHEMBL13265896 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1GLAKMT2AMEN1 | |
| SCHEMBL13265940 | 0.80 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1GLAKMT2AMEN1 | |
| SCHEMBL13265903 | 0.75 | RORC (0.62) | SMN1; SMN2ALDH1A1KMT2AMEN1GFER | |
| SCHEMBL13265902 | 0.75 | MAPT (0.60) | SMN1; SMN2ALDH1A1KMT2AMEN1GFER | |
| SCHEMBL13265979 | 0.74 | KMT2A (0.67) | SMN1; SMN2ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL13265967 | 0.74 | MEN1 (0.62) | SMN1; SMN2ALDH1A1KMT2AMEN1GFER | |
| SCHEMBL13265899 | 0.73 | RXFP1 (0.55) | SMN1; SMN2ALDH1A1KMT2AMEN1GFER | |
| SCHEMBL13265953 | 0.73 | RAB9A (0.66) | SMN1; SMN2ALDH1A1KMT2AMEN1GFER | |
| SCHEMBL13265904 | 0.72 | MAPT (0.57) | SMN1; SMN2ALDH1A1KMT2AMEN1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754773-B2 | Composition and synthesis of new reagents for inhibition of HIV replication | UNIVERSITY OF MASSACHUSETTS (US) | 2010-07-13 | — | — | US | disclosed |
| US-20070099919-A1 | Composition and synthesis of new reagents for inhibition of HIV replication | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099919-A1 | Composition and synthesis of new reagents for inhibition of HIV replication | REV1, MAVS, ISG15 | SMN1; SMN2 4378/4885ALDH1A1 4359/4885GLA 4106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.