Sugi Predict

Sugi Predict / Compounds / SCHEMBL132699

SCHEMBL132699

SCHEMBL132699

COc1ccc(C(OC[C@@]23CO[C@@H]([C@H](c4ccccc4)O2)[C@@H]3O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ SLC6A11 P48066 5/20 0.38
▸ SLC6A1 P30531 2/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ NPY2R P49146 1/20 0.34
▸ KIF11 P52732 3/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ SLC6A12 P48065 2/20 0.33
▸ TYMP P19971 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ SLC6A13 Q9NSD5 1/20 0.33
▸ KCNH2 Q12809 1/20 0.33
▸ LMNA P02545 1/20 0.32
▸ HTT P42858 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL169678 0.87 SLC5A2 (0.36) SLC6A11SLC6A1KIF11MEN1KMT2A
SCHEMBL169679 0.87 SLC5A2 (0.36) SLC6A11SLC6A1KIF11MEN1KMT2A
SCHEMBL6880054 0.87 SLC5A2 (0.36) SLC6A11SLC6A1KIF11MEN1KMT2A
SCHEMBL135522 0.86 SLC6A11 (0.35) SLC6A11SLC6A1NPY2RMEN1KMT2A
SCHEMBL169481 0.85 EGFR (0.35) SLC6A11SLC6A1L3MBTL1MEN1KMT2A
SCHEMBL169480 0.85 EGFR (0.35) SLC6A11SLC6A1L3MBTL1MEN1KMT2A
SCHEMBL133759 0.83 SLC6A1 (0.33) SLC6A11SLC6A1TP53LMNAHTT
SCHEMBL6277830 0.83 SLC6A1 (0.33) SLC6A11SLC6A1TP53LMNAHTT
SCHEMBL5878698 0.80 SLC6A11 (0.39) SLC6A11SLC6A1NPY2RMEN1KMT2A
SCHEMBL12386256 0.79 SLC6A11 (0.38) SLC6A11SLC6A1NPY2RKIF11MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9464106-B2 Oligonucleotides useful for detecting and analyzing nucleic acids of interest EXIQON A/S (DK) 2016-10-11 — — US disclosed
US-20120157333-A1 OLIGONUCLEOTIDES USEFUL FOR DETECTING AND ANALYZING NUCLEIC ACIDS OF INTEREST EXIQON A/S (DK) 2012-06-21 — — US disclosed
EP-1446412-B1 NOVEL LNA COMPOSITIONS AND USES THEREOF EXIQON AS (DK) 2012-03-07 — — EP disclosed
US-20070117144-A1 Oligonucleotides useful for detecting and analyzing nucleic acids of interest EXIQON A/S (DK) 2007-05-24 — — US disclosed
US-7060809-B2 LNA compositions and uses thereof EXIQON A/S (DE) 2006-06-13 — — US disclosed
US-20040219565-A1 Oligonucleotides useful for detecting and analyzing nucleic acids of interest EXIQON A/S (DK) 2004-11-04 — — US disclosed
US-20030224377-A1 Novel LNA compositions and uses thereof QIAGEN GMBH (DE) 2003-12-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040219565-A1 Oligonucleotides useful for detecting and analyzing nucleic acids of interest UPF1, DCLRE1B, SNRPA1 SLC6A11 4253/4885SLC6A1 4477/4885L3MBTL1 90/4885
US-20030224377-A1 Novel LNA compositions and uses thereof RNGTT, NCL, NSUN2 SLC6A11 2707/4885SLC6A1 2880/4885L3MBTL1 91/4885
US-20120157333-A1 OLIGONUCLEOTIDES USEFUL FOR DETECTING AND ANALYZING NUCLEIC ACIDS OF INTEREST UPF1, DCLRE1B, SNRPA1 SLC6A11 4253/4885SLC6A1 4477/4885L3MBTL1 90/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.