Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.49 |
| ▸ | CTSS | P25774 | 5/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.46 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | PPARG | P37231 | 5/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28804956 | 0.92 | CTSK (0.50) | CTSKCTSSCTSLCTSBFOLH1 | |
| SCHEMBL19000135 | 0.90 | CTSK (0.48) | CTSKCTSSCTSLCTSBCA1 | |
| SCHEMBL6168769 | 0.90 | CTSK (0.48) | CTSKCTSSCTSLCTSBCA1 | |
| SCHEMBL13621256 | 0.90 | CTSK (0.48) | CTSKCTSSCTSLCTSBCA1 | |
| SCHEMBL6168773 | 0.90 | CTSK (0.48) | CTSKCTSSCTSLCTSBCA1 | |
| SCHEMBL1318454 | 0.90 | CTSK (0.48) | CTSKCTSSCTSLCTSBCA1 | |
| SCHEMBL13263380 | 0.89 | NAALAD2 (0.59) | CTSKCTSSCTSLCTSBFOLH1 | |
| SCHEMBL20745305 | 0.89 | NAALAD2 (0.59) | CTSKCTSSCTSLCTSBFOLH1 | |
| SCHEMBL7066210 | 0.89 | NAALAD2 (0.59) | CTSKCTSSCTSLCTSBFOLH1 | |
| SCHEMBL1319454 | 0.89 | NAALAD2 (0.59) | CTSKCTSSCTSLCTSBFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9656949-B2 | Substituted carboxylic acid derivatives as aggrecanase inhibitors for the treatment of osteoarthritis | MERCK PATENT GMBH (DE) | 2017-05-23 | — | — | US | disclosed |
| EP-2953932-B1 | SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AS AGGRECANASE INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2017-03-01 | — | — | EP | disclosed |
| US-20150368188-A1 | SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AS AGGRECANASE INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2015-12-24 | — | — | US | disclosed |
| EP-2953932-A1 | SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AS AGGRECANASE INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Merck Patent GmbH (DE) | 2015-12-16 | — | — | EP | disclosed |
| WO-2014121884-A1 | SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AS AGGRECANASE INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2014-08-14 | — | — | WO | disclosed |
| US-20100152452-A1 | STEREOSELECTIVE SYNTHESIS OF PIPERIDINE DERIVATIVES | TAIGEN BIOTECHNOLOGY CO., LTD. (TW) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152452-A1 | STEREOSELECTIVE SYNTHESIS OF PIPERIDINE DERIVATIVES | DHPS, AZI2, DPYD | CTSK 4224/4885CTSS 3427/4885CTSL 4585/4885 |
| US-20150368188-A1 | SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AS AGGRECANASE INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | ADAMTS5, ADAMTS1, ADAMTS7 | CTSK 194/4885CTSS 154/4885CTSL 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.