Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1502483 | 0.77 | HSD11B1 (0.44) | MEN1KMT2AHSD11B1EPHX2 | |
| SCHEMBL13784388 | 0.72 | ENPP2 (0.37) | KMT2AHSD11B1 | |
| SCHEMBL13309763 | 0.69 | POLB (0.35) | KMT2AHSD11B1SMN1; SMN2HIF1A | |
| SCHEMBL1604392 | 0.69 | DGAT1 (0.45) | LMNA | |
| SCHEMBL12759864 | 0.69 | CYP3A4 (0.39) | KMT2AHSD11B1 | |
| SCHEMBL1548160 | 0.67 | SPHK2 (0.73) | MEN1KMT2AALDH1A1HSD11B1SMN1; SMN2 | |
| SCHEMBL5605482 | 0.66 | ENPP2 (0.42) | KMT2A | |
| SCHEMBL1604341 | 0.65 | PNMT (0.52) | — | |
| SCHEMBL1605275 | 0.64 | ENPP2 (0.38) | KMT2A | |
| SCHEMBL12759775 | 0.60 | DGAT1 (0.36) | ALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797034-B1 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2010-06-30 | — | — | EP | disclosed |