Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 4/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13784388 | 0.77 | ENPP2 (0.37) | HSD11B1KMT2A | |
| SCHEMBL13309656 | 0.77 | MEN1 (0.38) | HSD11B1EPHX2MEN1KMT2A | |
| SCHEMBL13309763 | 0.73 | POLB (0.35) | HSD11B1KMT2A | |
| SCHEMBL1604392 | 0.73 | DGAT1 (0.45) | — | |
| SCHEMBL12759864 | 0.72 | CYP3A4 (0.39) | HSD11B1KMT2A | |
| SCHEMBL13309977 | 0.72 | HSD11B1 (0.41) | HSD11B1THRBPAX8MAPK1 | |
| SCHEMBL5605482 | 0.70 | ENPP2 (0.42) | KMT2A | |
| SCHEMBL1604341 | 0.68 | PNMT (0.52) | — | |
| SCHEMBL1605275 | 0.67 | ENPP2 (0.38) | KMT2A | |
| SCHEMBL1502382 | 0.67 | L3MBTL1 (0.41) | HSD11B1EPHX2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915252-B2 | Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK SHARP & DOHME (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915252-B2 | Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK SHARP & DOHME (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915252-B2 | Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK SHARP & DOHME (US) | 2011-03-29 | — | — | US | disclosed |
| EP-1797034-B1 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2010-06-30 | — | — | EP | disclosed |
| EP-1797034-B1 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2010-06-30 | — | — | EP | disclosed |
| EP-1797034-A4 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO INC (US) | 2009-07-15 | — | — | EP | disclosed |
| US-20080318930-A1 | Sulfonyl Compound as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | MERCK SHARP & DOHME LLC | 2008-12-25 | — | — | US | disclosed |
| US-20080318930-A1 | Sulfonyl Compound as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | MERCK SHARP & DOHME LLC | 2008-12-25 | — | — | US | disclosed |
| US-20080318930-A1 | Sulfonyl Compound as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | MERCK SHARP & DOHME LLC | 2008-12-25 | — | — | US | disclosed |
| EP-1797034-A1 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | Merck & Co., Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006017542-A1 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO., INC. (US) | 2006-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318930-A1 | Sulfonyl Compound as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | HSD11B1, HSD17B1, HSD11B2 | HSD11B1 1/4885EPHX2 1817/4885THRB 1483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.