Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPG | P10696 | 4/20 | 0.39 |
| ▸ | PLAA | Q9Y263 | 2/20 | 0.39 |
| ▸ | FDPS | P14324 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 3/20 | 0.38 |
| ▸ | FPR2 | P25090 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13310633 | 0.85 | FPR2 (0.45) | ALPGPLAAFDPSCA12CA1 | |
| SCHEMBL13310544 | 0.81 | FPR2 (0.40) | ALPGPLAACA12CA1CA2 | |
| SCHEMBL11936765 | 0.77 | RAB9A (0.39) | ALPGPLAACA12CA1CA2 | |
| SCHEMBL13310650 | 0.76 | SMN1; SMN2 (0.54) | FDPSFPR2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12776032 | 0.75 | CYP1A2 (0.39) | FDPSALDH1A1KMT2AMEN1 | |
| SCHEMBL2427242 | 0.75 | FDPS (0.43) | ALPGPLAAFDPSCA12CA1 | |
| SCHEMBL1179644 | 0.74 | ALPL (0.53) | ALPGPLAAFDPSCA12CA1 | |
| SCHEMBL11930757 | 0.74 | LMNA (0.38) | ALPGPLAACA12CA1CA2 | |
| SCHEMBL22176033 | 0.73 | FDPS (0.36) | FDPSALDH1A1KMT2AMEN1 | |
| SCHEMBL19033087 | 0.70 | LMNA (0.36) | ALPGPLAACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309544-B2 | Spiroindalones | MERCK SHARP & DOHME CORP. (US) | 2012-11-13 | — | — | US | disclosed |
| US-20100137297-A1 | SPIROINDALONES | MERCK SHARP & DOHME LLC | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137297-A1 | SPIROINDALONES | HIF1AN, HIF1A, EGLN2 | ALPG 4515/4885PLAA 4580/4885FDPS 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.