Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 9/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1333116 | 0.89 | HTR1A (0.49) | CYP2D6CYP2C9CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL27768291 | 0.83 | ADRA1D (0.59) | CYP2D6CYP2C9CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL1333911 | 0.83 | SIGMAR1 (0.61) | SIGMAR1EBPTMEM97ADRA1DADRA1A | |
| SCHEMBL6575640 | 0.81 | CYP2D6 (0.60) | CYP2D6CYP2C9CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL1333990 | 0.81 | SIGMAR1 (0.57) | LMNAMAPTKMT2ASIGMAR1EBP | |
| SCHEMBL10511350 | 0.80 | ABCB1 (0.45) | CYP2D6CYP2C9CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL1333135 | 0.80 | SIGMAR1 (0.56) | MEN1KMT2ASIGMAR1EBPTMEM97 | |
| SCHEMBL1334251 | 0.80 | SIGMAR1 (0.56) | LMNAMAPTSIGMAR1EBPTMEM97 | |
| SCHEMBL1332200 | 0.79 | SIGMAR1 (0.69) | SIGMAR1EBPTMEM97ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL1333220 | 0.79 | SIGMAR1 (0.55) | SIGMAR1EBPTMEM97ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101511187-B | Piperidine and piperazine derivatives | MS SCIENCE CORP | 2012-07-04 | — | — | CN | disclosed |
| US-8183374-B2 | Piperidine and piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2012-05-22 | — | — | US | disclosed |
| US-20110281890-A1 | Piperidine and piperazine derivatives | M'S SCIENCE CORPORATION | 2011-11-17 | — | — | US | disclosed |
| EP-1978959-B1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2011-11-09 | — | — | EP | disclosed |
| EP-2340835-A1 | Piperidine and piperazine derivatives | M's Science Corporation (JP) | 2011-07-06 | — | — | EP | disclosed |
| CN-101448503-B | Piperidine and piperazine derivatives | MS SCIENCE CORP | 2011-04-13 | — | — | CN | disclosed |
| EP-1976525-B1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2010-11-03 | — | — | EP | disclosed |
| US-20100256162-A1 | Piperazine and Piperidine Derivatives | AGY THERAPEUTICS, INC. (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100137334-A1 | Piperidine and Piperazine Derivatives | SUN CONNIE L | 2010-06-03 | — | — | US | disclosed |
| CN-101511187-A | Piperidine and piperazine derivatives | MS SCIENCE CORP (JP) | 2009-08-19 | — | — | CN | disclosed |
| CN-101448503-A | Piperidine and piperazine derivatives | MS SCIENCE CORP (JP) | 2009-06-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137334-A1 | Piperidine and Piperazine Derivatives | SIGMAR1, OPRM1, OPRD1 | CYP2D6 1045/4885CYP2C9 2102/4885CYP1A2 268/4885 |
| US-20110281890-A1 | Piperidine and piperazine derivatives | SIGMAR1, OPRM1, OPRD1 | CYP2D6 1037/4885CYP2C9 2190/4885CYP1A2 483/4885 |
| US-20100256162-A1 | Piperazine and Piperidine Derivatives | SIGMAR1, OPRM1, OPRD1 | CYP2D6 1057/4885CYP2C9 2291/4885CYP1A2 486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.