Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | GLP1R | P43220 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2663106 | 0.87 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2RAB9AKDM4ENPC1 | |
| SCHEMBL8131965 | 0.85 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2RAB9AKDM4ENPC1 | |
| SCHEMBL18498935 | 0.85 | IDO1 (0.56) | ALDH1A1SMN1; SMN2RAB9AKDM4ENPC1 | |
| SCHEMBL12207094 | 0.84 | TBXA2R (0.59) | ALDH1A1SMN1; SMN2RAB9AKDM4ENPC1 | |
| SCHEMBL8575945 | 0.83 | MAPT (0.63) | ALDH1A1KDM4EHPGDGAAUSP2 | |
| SCHEMBL13330103 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KDM4EGAAUSP2MAPT | |
| SCHEMBL12207107 | 0.82 | CA12 (0.61) | ALDH1A1SMN1; SMN2RAB9AKDM4ENPC1 | |
| SCHEMBL9464524 | 0.81 | CA12 (0.61) | ALDH1A1SMN1; SMN2RAB9AKDM4EGAA | |
| SCHEMBL3103190 | 0.81 | MEP1B (0.67) | ALDH1A1SMN1; SMN2RAB9AKDM4ENPC1 | |
| SCHEMBL2464132 | 0.80 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2RAB9AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113386-A1 | N-BENZYL SUBSTITUTED PYRIDYL PORPHYRIN COMPOUNDS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2010-05-06 | — | — | US | disclosed |
| US-20100113386-A1 | N-BENZYL SUBSTITUTED PYRIDYL PORPHYRIN COMPOUNDS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2010-05-06 | — | — | US | disclosed |
| US-7642250-B2 | N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2010-01-05 | — | — | US | disclosed |
| US-7642250-B2 | N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2010-01-05 | — | — | US | disclosed |
| WO-2007038630-A2 | N-BENZYL SUBSTITUTED PYRIDYL PORPHYRIN COMPOUNDS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |
| US-20070072825-A1 | N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-03-29 | — | — | US | disclosed |
| US-20070072825-A1 | N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113386-A1 | N-BENZYL SUBSTITUTED PYRIDYL PORPHYRIN COMPOUNDS AND METHODS OF USE THEREOF | PPOX, PPIF, COX5A | ALDH1A1 1624/4885SMN1; SMN2 97/4885RAB9A 3307/4885 |
| US-20070072825-A1 | N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof | PPOX, PPIF, COX5A | ALDH1A1 1624/4885SMN1; SMN2 97/4885RAB9A 3307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.