Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | CCNH | P51946 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17776579 | 1.00 | SMYD3 (0.39) | SMYD3MDM2GAAL3MBTL1IRAK4 | |
| SCHEMBL31963 | 1.00 | SMYD3 (0.39) | SMYD3MDM2GAAL3MBTL1IRAK4 | |
| SCHEMBL23333333 | 0.87 | SMYD3 (0.37) | SMYD3MDM2GAAL3MBTL1 | |
| SCHEMBL2600363 | 0.86 | MDM2 (0.41) | MDM2GAAL3MBTL1IRAK4DRD2 | |
| SCHEMBL16171239 | 0.86 | MDM2 (0.41) | MDM2GAAL3MBTL1IRAK4DRD2 | |
| SCHEMBL681668 | 0.86 | — | — | |
| SCHEMBL18458286 | 0.86 | MDM2 (0.41) | MDM2GAAL3MBTL1IRAK4DRD2 | |
| SCHEMBL17776569 | 0.85 | MDM2 (0.41) | SMYD3MDM2CCNT1CDK4CCND1 | |
| SCHEMBL2621567 | 0.85 | MDM2 (0.41) | SMYD3MDM2CCNT1CDK4CCND1 | |
| SCHEMBL17776568 | 0.85 | MDM2 (0.41) | SMYD3MDM2CCNT1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018150-A1 | SMALL MOLECULAR INHIBITOR AGAINST BTK AND/OR BTK C481S AND USE THEREOF | ARROMAX PHARMATECH CO., LTD. (CN) | 2024-01-18 | — | — | US | disclosed |
| US-20230062975-A1 | HEPATITIS B CAPSID ASSEMBLY MODULATORS | SPRING MILL PHARMA, INC. | 2023-03-02 | — | — | US | disclosed |
| US-20210085714-A1 | EXPANSION OF NK AND DC CELLS IN VIVO MEDIATING IMMUNE RESPONSE | UNIVERSITE DE MONTREAL (CA) | 2021-03-25 | — | — | US | disclosed |
| US-20210087290-A1 | COMPOUNDS WHICH SPECIFICALLY BIND TO CD38 FOR USE IN THE TREATMENT OF NEURODEGENERATIVE AND INFLAMMATORY DISEASES | ENCEFA (FR) | 2021-03-25 | — | — | US | disclosed |
| EP-3221306-B1 | HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-11-13 | — | — | EP | disclosed |
| US-10414763-B2 | Azaquinazoline inhibitors of atypical protein kinase C | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2019-09-17 | — | — | US | disclosed |
| US-10336747-B2 | Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells | Université de Montréal | 2019-07-02 | — | — | US | disclosed |
| US-10273503-B2 | Compounds and methods for enhancing viral gene transfer to human hematopoietic cells | UNIVERSITE DE MONTREAL (CA) | 2019-04-30 | — | — | US | disclosed |
| WO-2019005977-A1 | TRIOXOLANE AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-01-03 | — | — | WO | disclosed |
| US-10030013-B2 | Heteroaryl compounds as IRAK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2018-07-24 | — | — | US | disclosed |
| US-20180002327-A1 | HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2018-01-04 | — | — | US | disclosed |
| US-9790221-B2 | Heteroaryl compounds as IRAK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2017-10-17 | — | — | US | disclosed |
| US-9790221-B2 | Heteroaryl compounds as IRAK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2017-10-17 | — | — | US | disclosed |
| US-20170037047-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | UNIVERSITE DE MONTREAL (CA) | 2017-02-09 | — | — | US | disclosed |
| US-9409906-B2 | Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells | UNIVERSITE DE MONTREAL (CA) | 2016-08-09 | — | — | US | disclosed |
| US-20160145252-A1 | HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-05-26 | — | — | US | disclosed |
| US-9296744-B2 | — | — | 2016-03-29 | — | — | US | disclosed |
| US-20150274720-A1 | Azaquinazoline Inhibitors Of Atypical Protein Kinase C | WINDTREE THERAPEUTICS, INC. | 2015-10-01 | — | — | US | disclosed |
| US-20150011543-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | UNIVERSITE DE MONTREAL (CA) | 2015-01-08 | — | — | US | disclosed |
| US-20100130469-A1 | 2, 6-NAPHTHRIDINE DERIVATIVES | VAN EIS MAURICE | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10273503-B2 | Compounds and methods for enhancing viral gene transfer to human hematopoietic cells | HCLS1, INMT, IDO1 | SMYD3 1804/4885MDM2 2795/4885GAA 1897/4885 |
| US-20210085714-A1 | EXPANSION OF NK AND DC CELLS IN VIVO MEDIATING IMMUNE RESPONSE | PBK, CD74, IL17A | SMYD3 2709/4885MDM2 3613/4885GAA 4144/4885 |
| US-10030013-B2 | Heteroaryl compounds as IRAK inhibitors and uses thereof | IRAK2, IRAK3, IRAK1 | SMYD3 3381/4885MDM2 192/4885GAA 1757/4885 |
| US-20230062975-A1 | HEPATITIS B CAPSID ASSEMBLY MODULATORS | HAVCR2, COPB1, HDLBP | SMYD3 3711/4885MDM2 2375/4885GAA 1088/4885 |
| US-20160145252-A1 | HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | SMYD3 3381/4885MDM2 192/4885GAA 1757/4885 |
| US-20100130469-A1 | 2, 6-NAPHTHRIDINE DERIVATIVES | PKN1, PKN2, CDK9 | SMYD3 3018/4885MDM2 2434/4885GAA 2238/4885 |
| US-20170037047-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | HPGDS, HCLS1, THPO | SMYD3 2716/4885MDM2 4332/4885GAA 373/4885 |
| US-20210087290-A1 | COMPOUNDS WHICH SPECIFICALLY BIND TO CD38 FOR USE IN THE TREATMENT OF NEURODEGENERATIVE AND INFLAMMATORY DISEASES | CD38, TRPC1, TRPC4 | SMYD3 4122/4885MDM2 4524/4885GAA 763/4885 |
| US-10414763-B2 | Azaquinazoline inhibitors of atypical protein kinase C | PRKCQ, PRKCA, PRKCZ | SMYD3 1432/4885MDM2 2447/4885GAA 3147/4885 |
| US-20180002327-A1 | HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | SMYD3 3381/4885MDM2 192/4885GAA 1757/4885 |
| US-10336747-B2 | Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells | IDO1, IDO2, INMT | SMYD3 2252/4885MDM2 873/4885GAA 3383/4885 |
| US-20150274720-A1 | Azaquinazoline Inhibitors Of Atypical Protein Kinase C | PRKCQ, PRKCA, PRKCZ | SMYD3 1432/4885MDM2 2447/4885GAA 3147/4885 |
| US-20240018150-A1 | SMALL MOLECULAR INHIBITOR AGAINST BTK AND/OR BTK C481S AND USE THEREOF | BTK, SYK, LCK | SMYD3 2479/4885MDM2 1572/4885GAA 2940/4885 |
| US-20150011543-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | IDO1, IDO2, INMT | SMYD3 2252/4885MDM2 873/4885GAA 3383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.