Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6113531 | 1.00 | MAPT (0.35) | MAPTGAAMCHR1PTPN2PTPN1 | |
| SCHEMBL1333774 | 1.00 | MAPT (0.35) | MAPTGAAMCHR1PTPN2PTPN1 | |
| SCHEMBL8771837 | 0.87 | MAPK14 (0.41) | MAPTGAAMCHR1MAPK14DGAT1 | |
| SCHEMBL21117214 | 0.81 | MAPT (0.43) | MAPTGAADGAT1MEN1KMT2A | |
| SCHEMBL10973475 | 0.81 | CYP2C9 (0.49) | MAPTGAADGAT1MEN1KMT2A | |
| SCHEMBL10973478 | 0.81 | CYP2C9 (0.49) | MAPTGAADGAT1MEN1KMT2A | |
| SCHEMBL10973480 | 0.81 | CYP2C9 (0.49) | MAPTGAADGAT1MEN1KMT2A | |
| SCHEMBL9936081 | 0.80 | GBA1 (0.34) | MAPTGAAMCHR1MAPK14DGAT1 | |
| SCHEMBL9936085 | 0.80 | GBA1 (0.34) | MAPTGAAMCHR1MAPK14DGAT1 | |
| SCHEMBL9936079 | 0.80 | GBA1 (0.34) | MAPTGAAMCHR1MAPK14DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3621958-B1 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | TRANSITIONS OPTICAL LTD (IE) | 2024-07-10 | — | — | EP | claimed |
| EP-3071576-B9 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2021-12-22 | — | — | EP | claimed |
| EP-3071576-B1 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2021-08-18 | — | — | EP | claimed |
| EP-3621958-A1 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | Transitions Optical, Ltd. (IE) | 2020-03-18 | — | — | EP | claimed |
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | TRANSITIONS OPTICAL, LTD. (IE) | 2020-02-13 | — | — | US | claimed |
| EP-2970760-B1 | PHOTOCHROMIC ARTICLES THAT INCLUDE PHOTOCHROMIC-DICHROIC MATERIALS | TRANSITIONS OPTICAL INC (US) | 2019-06-26 | — | — | EP | claimed |
| US-10145996-B2 | Photochromic articles that include photochromic-dichroic materials | TRANSITIONS OPTICAL, INC. (US) | 2018-12-04 | — | — | US | claimed |
| WO-2018206096-A1 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | TRANSITIONS OPTICAL, LTD. (IE) | 2018-11-15 | — | — | WO | claimed |
| EP-3268375-A1 | PHOTOCHROMIC THIENOCHROMENE COMPOUNDS | Transitions Optical, Inc. (US) | 2018-01-17 | — | — | EP | claimed |
| EP-3071576-A1 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | Transitions Optical, Inc. (US) | 2016-09-28 | — | — | EP | claimed |
| EP-2652552-B9 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL INC (US) | 2016-02-17 | — | — | EP | claimed |
| EP-2652552-B1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL INC (US) | 2015-09-02 | — | — | EP | claimed |
| US-9051332-B1 | Photochromic indeno-fused ring pyran compounds | TRANSITIONS OPTICAL, INC. (US) | 2015-06-09 | — | — | US | claimed |
| WO-2015077141-A1 | FUSED RING INDENO COMPOUNDS FOR PREPARATION OF PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2015-05-28 | — | — | WO | claimed |
| WO-2015077264-A1 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2015-05-28 | — | — | WO | claimed |
| US-20150141661-A1 | Photochromic Indeno-Fused Ring Pyran Compounds | TRANSITIONS OPTICAL, INC. (US) | 2015-05-21 | — | — | US | claimed |
| US-9029565-B1 | Fused ring indeno compounds for preparation of photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2015-05-12 | — | — | US | claimed |
| US-20140272468-A1 | PHOTOCHROMIC ARTICLES THAT INCLUDE PHOTOCHROMIC-DICHROIC MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2014-09-18 | — | — | US | claimed |
| US-8545984-B2 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2013-10-01 | — | — | US | claimed |
| US-20110129678-A1 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2011-06-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | ALDH1A2, RB1, INCENP | MAPT 1822/4885GAA 2440/4885MCHR1 288/4885 |
| US-20110129678-A1 | Photochromic compounds and compositions | CRY2, CRY1, PPOX | MAPT 573/4885GAA 4645/4885MCHR1 2392/4885 |
| US-20150141661-A1 | Photochromic Indeno-Fused Ring Pyran Compounds | INF2, INCENP, RB1 | MAPT 2708/4885GAA 4505/4885MCHR1 1268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.