Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.71 |
| ▸ | LTA4H | P09960 | 3/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 2/20 | 0.63 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.63 |
| ▸ | DRD2 | P14416 | 1/20 | 0.63 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1334031 | 0.99 | SIGMAR1 (0.69) | SIGMAR1LTA4HKCNH2HRH3DRD3 | |
| SCHEMBL13150797 | 0.96 | SIGMAR1 (0.72) | SIGMAR1LTA4HKCNH2HRH3DRD3 | |
| SCHEMBL13150791 | 0.91 | DRD3 (0.72) | LTA4HDRD3KCNA5DRD2 | |
| SCHEMBL13150788 | 0.88 | SIGMAR1 (0.88) | SIGMAR1KCNH2HRH3SMPD1 | |
| SCHEMBL1334087 | 0.88 | LTA4H (0.71) | SIGMAR1LTA4HKCNH2HRH3 | |
| SCHEMBL2157291 | 0.87 | SIGMAR1 (0.69) | SIGMAR1LTA4HKCNH2HRH3DRD3 | |
| Hydrochloric Acid SCHEMBL1334253 | 0.86 | KCNH2 (0.73) | SIGMAR1LTA4HKCNH2HRH3 | |
| SCHEMBL1333781 | 0.86 | SIGMAR1 (0.78) | SIGMAR1LTA4HKCNH2HRH3 | |
| SCHEMBL1334138 | 0.85 | LTA4H (0.60) | SIGMAR1LTA4HKCNH2HRH3 | |
| Hydrochloric Acid SCHEMBL1333229 | 0.85 | SIGMAR1 (0.76) | SIGMAR1LTA4HKCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101511187-B | Piperidine and piperazine derivatives | MS SCIENCE CORP | 2012-07-04 | — | — | CN | claimed |
| EP-1978959-B1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2011-11-09 | — | — | EP | claimed |
| US-20100256162-A1 | Piperazine and Piperidine Derivatives | AGY THERAPEUTICS, INC. (US) | 2010-10-07 | — | — | US | claimed |
| US-20100137334-A1 | Piperidine and Piperazine Derivatives | SUN CONNIE L | 2010-06-03 | — | — | US | claimed |
| EP-1978959-A4 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2009-09-02 | — | — | EP | claimed |
| EP-1976525-A4 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2009-07-15 | — | — | EP | claimed |
| EP-1978959-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-10-15 | — | — | EP | claimed |
| EP-1976525-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-10-08 | — | — | EP | claimed |
| WO-2008096189-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2008-08-14 | — | — | WO | claimed |
| WO-2007089462-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-08-09 | — | — | WO | claimed |
| US-20130072497-A1 | N- SUBSTITUTED PIPERAZINES | DOW AGROSCIENCES LLC (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072497-A1 | N- SUBSTITUTED PIPERAZINES | DOW AGROSCIENCES LLC (US) | 2013-03-21 | — | — | US | disclosed |
| US-8338430-B2 | N-substituted piperazines | DOW AGROSCIENCES, LLC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338430-B2 | N-substituted piperazines | DOW AGROSCIENCES, LLC. (US) | 2012-12-25 | — | — | US | disclosed |
| CN-101511187-B | Piperidine and piperazine derivatives | MS SCIENCE CORP | 2012-07-04 | — | — | CN | disclosed |
| WO-2008096189-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2008-08-14 | — | — | WO | disclosed |
| WO-2007089462-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007089462-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-08-09 | — | — | WO | disclosed |
| US-20070004750-A1 | N-substituted piperazines | CORTEVA AGRISCIENCE LLC | 2007-01-04 | — | — | US | disclosed |
| US-20070004750-A1 | N-substituted piperazines | CORTEVA AGRISCIENCE LLC | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004750-A1 | N-substituted piperazines | PRXL2A, CNPY2, CYP4X1 | SIGMAR1 251/4885LTA4H 3316/4885KCNH2 87/4885 |
| US-20100137334-A1 | Piperidine and Piperazine Derivatives | SIGMAR1, OPRM1, OPRD1 | SIGMAR1 1/4885LTA4H 2934/4885KCNH2 332/4885 |
| US-20130072497-A1 | N- SUBSTITUTED PIPERAZINES | PRXL2A, CNPY2, CYP4X1 | SIGMAR1 251/4885LTA4H 3316/4885KCNH2 87/4885 |
| US-20100256162-A1 | Piperazine and Piperidine Derivatives | SIGMAR1, OPRM1, OPRD1 | SIGMAR1 1/4885LTA4H 3616/4885KCNH2 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.