Sugi Predict

Sugi Predict / Compounds / SCHEMBL1334286

SCHEMBL1334286

SCHEMBL1334286

CS(=O)(=O)OCCCc1ccc(Cl)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.48
▸ ALOX15 P16050 2/20 0.48
▸ TSHR P16473 2/20 0.48
▸ KDM4E B2RXH2 1/20 0.48
▸ USP2 O75604 1/20 0.48
▸ LMNA P02545 1/20 0.48
▸ MMP9 P14780 1/20 0.48
▸ SLC6A2 P23975 2/20 0.42
▸ HRH1 P35367 2/20 0.42
▸ HRH3 Q9Y5N1 2/20 0.42
▸ CHRM2 P08172 1/20 0.42
▸ ADRA2C P18825 1/20 0.42
▸ SLC6A4 P31645 1/20 0.42
▸ SLC6A3 Q01959 1/20 0.42
▸ KCNH2 Q12809 1/20 0.42
▸ CACNA1C Q13936 1/20 0.42
▸ SCN5A Q14524 1/20 0.42
▸ CHRM4 P08173 1/20 0.41
▸ HTR2C P28335 1/20 0.41
▸ HTR7 P34969 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11279959 0.95 TSHR (0.52) ALDH1A1ALOX15TSHRKDM4EUSP2
SCHEMBL1284072 0.89 CA1 (0.43) ALDH1A1ALOX15TSHRKDM4EUSP2
SCHEMBL3540841 0.85 ALDH1A1 (0.52) ALDH1A1ALOX15TSHRKDM4EUSP2
SCHEMBL6284410 0.84 ALDH1A1 (0.50) ALDH1A1ALOX15TSHRKDM4EUSP2
SCHEMBL2453322 0.84 ALDH1A1 (0.50) ALDH1A1ALOX15TSHRKDM4EUSP2
SCHEMBL6283344 0.84 CA2 (0.53) ALDH1A1ALOX15TSHRKDM4EUSP2
SCHEMBL6618852 0.83 ALDH1A1 (0.45) ALDH1A1ALOX15TSHRKDM4EUSP2
SCHEMBL10789846 0.83 TAAR1 (0.38) ALDH1A1ALOX15TSHRKDM4EUSP2
SCHEMBL4970012 0.82 KDM4E (0.48) ALDH1A1ALOX15TSHRKDM4EUSP2
SCHEMBL408714 0.82 TSHR (0.48) ALDH1A1ALOX15TSHRKDM4EUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4732903-A1 CO-CRYSTALS OF PITOLISANT HYDROCHLORIDE BIOPROJET Pharma (FR) 2026-04-29 — — EP disclosed
EP-4688166-A1 POLYMORPH FORM OF PITOLISANT HYDROCHLORIDE BIOPROJET Pharma (FR) 2026-02-11 — — EP disclosed
US-20250154117-A1 POLYMORPH FORM OF PITOLISANT HYDROCHLORIDE BIOPROJET PHARMA (FR) 2025-05-15 — — US disclosed
WO-2024201139-A1 POLYMORPH FORM OF PITOLISANT HYDROCHLORIDE BIOPROJET PHARMA (FR) 2024-10-03 — — WO disclosed
US-11945788-B2 Process for preparing pitolisant hydrochloride and solid-state forms thereof NURAY CHEMICALS PRIVATE LIMITED (IN) 2024-04-02 — — US disclosed
US-20230219914-A1 PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF Nuray Chemicals Private Limiited (IN) 2023-07-13 — — US disclosed
US-20230219914-A1 PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF Nuray Chemicals Private Limiited (IN) 2023-07-13 — — US disclosed
US-20230219914-A1 PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF Nuray Chemicals Private Limiited (IN) 2023-07-13 — — US disclosed
US-11623920-B2 Process for preparing pitolisant hydrochloride and solid-state forms thereof NURAY CHEMICALS PRIVATE LIMITED (IN) 2023-04-11 — — US disclosed
US-20220402886-A1 PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF Nuray Chemicals Private Lmiited (IN) 2022-12-22 — — US disclosed
US-5731432-A Inhibitors of adenosine monophosphate deaminase GENSIA SICOR INC. (US) 1998-03-24 — — US disclosed
WO-1997049690-A1 A METHOD FOR TREATING MENIERE'S DISEASE MERCK & CO., INC. (US) 1997-12-31 — — WO disclosed
CN-1142184-A Antiarrhythmic benzodiazepines * MERCK & CO INC (US) 1997-02-05 — — CN disclosed
US-5595990-A TREATMENT OF CARDIOVASCULAR DISORDERS MERCK & CO., INC. (US) 1997-01-21 — — US disclosed
EP-0730454-A1 ANTIARRHYTHMIC BENZODIAZEPINES MERCK & CO. INC. (US) 1996-09-11 — — EP disclosed
US-5426185-A Antiarrhythmia agents having reduced side effects MERCK & CO., INC. (US) 1995-06-20 — — US disclosed
WO-1995014471-A1 ANTIARRHYTHMIC BENZODIAZEPINES MERCK & CO., INC. (US) 1995-06-01 — — WO disclosed
WO-1994018200-A1 NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE GENSIA, INC. (US) 1994-08-18 — — WO disclosed
US-4489094-A Arylalkylaminobenzoic acids AMERICAN CYANAMID COMPANY (US) 1984-12-18 — — US disclosed
US-4363805-A TREATMENT OF CORONARY DISEASE FIRMA WILLMAR SCHWABE (DE) 1982-12-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220402886-A1 PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF PITHD1, MLN, TPP1 ALDH1A1 810/4885ALOX15 3558/4885TSHR 2010/4885
US-11945788-B2 Process for preparing pitolisant hydrochloride and solid-state forms thereof PITHD1, MLN, TPP1 ALDH1A1 810/4885ALOX15 3558/4885TSHR 2010/4885
US-20230219914-A1 PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF PITHD1, MLN, TPP1 ALDH1A1 810/4885ALOX15 3558/4885TSHR 2010/4885
US-11623920-B2 Process for preparing pitolisant hydrochloride and solid-state forms thereof PITHD1, MLN, TPP1 ALDH1A1 810/4885ALOX15 3558/4885TSHR 2010/4885
US-20250154117-A1 POLYMORPH FORM OF PITOLISANT HYDROCHLORIDE PRNP, HLA-DRB1, PITHD1 ALDH1A1 2345/4885ALOX15 3968/4885TSHR 2726/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.