Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.62 |
| ▸ | HTR1A | P08908 | 5/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.62 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.62 |
| ▸ | HTR3B | O95264 | 4/20 | 0.62 |
| ▸ | HTR3A | P46098 | 4/20 | 0.62 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.62 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.62 |
| ▸ | HTR2C | P28335 | 3/20 | 0.62 |
| ▸ | HTR6 | P50406 | 3/20 | 0.62 |
| ▸ | THRB | P10828 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27906847 | 0.94 | ADRB1 (0.55) | HTR7HTR1AADRB1HTR3EHTR3B | |
| Tert-Butyl Formate SCHEMBL28048661 | 0.87 | ADRB1 (0.50) | HTR7HTR1AADRB1HTR3EHTR3B | |
| SCHEMBL1443579 | 0.84 | TRIM24 (0.60) | HTR7ALDH1A1MAPT | |
| SCHEMBL29377692 | 0.84 | TRIM24 (0.60) | HTR7ALDH1A1MAPT | |
| SCHEMBL13118679 | 0.83 | HTR7 (0.57) | HTR7HTR1AADRB1HTR3EHTR3B | |
| SCHEMBL1418736 | 0.82 | ALDH1A1 (0.61) | HTR7HTTALDH1A1MAPT | |
| SCHEMBL30770827 | 0.82 | ALDH1A1 (0.61) | HTR7HTTALDH1A1MAPT | |
| SCHEMBL13118667 | 0.81 | HTR1A (0.63) | HTR7HTR1AADRB1HTR3EHTR3B | |
| SCHEMBL31611878 | 0.80 | HTR3E (0.63) | HTR7HTR1AADRB1HTR3EHTR3B | |
| SCHEMBL31247769 | 0.79 | ALDH3A1 (0.55) | HTR7CYP1A2CYP3A4CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-11225655-B2 | Bi-functional complexes and methods for making and using such complexes | NUEVOLUTION A/S (DK) | 2022-01-18 | — | — | US | disclosed |
| EP-3540059-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | Nuevolution A/S (DK) | 2019-09-18 | — | — | EP | disclosed |
| EP-2558577-B1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION AS (DK) | 2018-12-12 | — | — | EP | disclosed |
| US-20130281324-A1 | BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2013-10-24 | — | — | US | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |