Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSF1 | Q00613 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 8/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | ATP4A | P20648 | 3/20 | 0.41 |
| ▸ | ATP4B | P51164 | 3/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6569582 | 0.86 | HSF1 (0.48) | HSF1LTA4HKCNH2LOXL2ATP4A | |
| SCHEMBL6569010 | 0.80 | HSF1 (0.47) | HSF1LTA4HKCNH2LOXL2ATP4A | |
| SCHEMBL1334787 | 0.74 | LTA4H (0.50) | HSF1LTA4HKCNH2LOXL2ATP4A | |
| SCHEMBL2782358 | 0.69 | MGLL (0.46) | MGLLHPGDRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL31010170 | 0.69 | LTA4H (0.58) | LTA4HKCNH2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL12465076 | 0.68 | LOXL2 (0.60) | LOXL2HPGDRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL30093448 | 0.68 | LOXL2 (0.60) | LOXL2HPGDRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29447341 | 0.67 | KCNH2 (0.59) | LTA4HKCNH2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7773349 | 0.66 | HTR1A (0.50) | LOXL2HPGDRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL491694 | 0.66 | LTA4H (0.78) | LTA4HKCNH2ATP4AATP4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100503-B1 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H 3?-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ILE BIOPROJET SOC CIV (FR) | 2004-09-22 | — | — | EP | claimed |
| US-20110281844-A1 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | SCHWARTZ JEAN-CHARLES (FR) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281844-A1 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | HRH3, HRH4, HRH2 | HSF1 2541/4885LTA4H 511/4885KCNH2 427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.