Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL10790076 | 0.80 | CTNNB1 (0.39) | L3MBTL1KDM4ENPSR1SMN1; SMN2HSD17B10 | |
| SCHEMBL500126 | 0.80 | KDM4E (0.45) | ALDH1A1MAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL27812775 | 0.76 | ALOX5 (0.52) | L3MBTL1GLAALDH1A1MAPTKDM4E | |
| Phosphoric Acid SCHEMBL403831 | 0.75 | L3MBTL1 (0.38) | L3MBTL1ALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL29382582 | 0.73 | FABP4 (0.35) | ALDH1A1MAPTHPGDNPC1RAB9A | |
| SCHEMBL14896404 | 0.73 | MAPK1 (0.37) | L3MBTL1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL10708885 | 0.73 | FABP4 (0.38) | ALDH1A1MAPTHPGDNPC1RAB9A | |
| SCHEMBL28784939 | 0.72 | FABP4 (0.43) | L3MBTL1ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL5512635 | 0.72 | KDM4E (0.44) | ALDH1A1MAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL530231 | 0.72 | MKNK1 (0.43) | ALDH1A1HDAC6MAPTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1486536-B2 | FLAME-RETARDANT RESIN COMPOSITION | POLYPLASTICS CO (JP) | 2012-10-10 | — | — | EP | disclosed |
| EP-1452567-B1 | FLAME-RETARDANT RESIN COMPOSITION | POLYPLASTICS CO (JP) | 2012-03-07 | — | — | EP | disclosed |
| EP-1466946-B1 | FLAME-RETARDANT RESIN COMPOSITION | POLYPLASTICS CO (JP) | 2011-11-09 | — | — | EP | disclosed |
| US-7498375-B2 | Flame-retardant resin composition | POLYPLASTICS CO., LTD. (JP) | 2009-03-03 | — | — | US | disclosed |
| US-7411013-B2 | Flame-retardant resin composition | POLYPLASTICS CO., LTD. (JP) | 2008-08-12 | — | — | US | disclosed |
| US-20070135540-A1 | Thermoplastic resin composition and injection-molded article thereof | POLYPLASTICS CO., LTD. (JP) | 2007-06-14 | — | — | US | disclosed |
| US-7205346-B2 | halogen-free, fireproof mixture of thermoplastic resins, containing phosphorus compounds, aromatic resins, nitrogen compounds, metal compounds, stabilizer agents and water repellants | POLYPLASTICS CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |
| EP-1486536-B1 | FLAME-RETARDANT RESIN COMPOSITION | POLYPLASTICS CO (JP) | 2007-01-24 | — | — | EP | disclosed |
| US-7115677-B2 | Flame-retardant resin composition | POLYPLASTICS CO., LTD. (JP) | 2006-10-03 | — | — | US | disclosed |
| US-20060074154-A1 | Flame-retardant resin composition | POLYPLASTICS CO., LTD. (JP) | 2006-04-06 | — | — | US | disclosed |
| US-20050004292-A1 | Flame-retardant resin composition | POLYPLASTICS CO., LTD. (JP) | 2005-01-06 | — | — | US | disclosed |
| US-20040266916-A1 | Flame-retardant resin composition | POLYPLASTICS CO., LTD. (JP) | 2004-12-30 | — | — | US | disclosed |
| US-20040254270-A1 | Flame-retardant resin composition | POLYPLASTICS CO., LTD. (JP) | 2004-12-16 | — | — | US | disclosed |
| EP-1486536-A1 | FLAME-RETARDANT RESIN COMPOSITION | Polyplastics Co Ltd (JP) | 2004-12-15 | — | — | EP | disclosed |
| EP-1466946-A1 | FLAME-RETARDANT RESIN COMPOSITION | Polyplastics Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-1452567-A1 | FLAME-RETARDANT RESIN COMPOSITION | Polyplastics Co Ltd (JP) | 2004-09-01 | — | — | EP | disclosed |