Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL529917 | 0.83 | IKBKB (0.47) | MKNK1MKNK2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL29686816 | 0.79 | TSHR (0.53) | MKNK1MKNK2ALDH1A1MAPTKDM4E | |
| SCHEMBL28706339 | 0.79 | TSHR (0.53) | MKNK1MKNK2ALDH1A1MAPTKDM4E | |
| SCHEMBL5504641 | 0.78 | BCAT2 (0.57) | MKNK1MKNK2ALDH1A1MAPTKDM4E | |
| SCHEMBL4065289 | 0.77 | BCAT2 (0.43) | MKNK1MKNK2ALDH1A1MAPTKDM4E | |
| SCHEMBL28309500 | 0.76 | L3MBTL1 (0.45) | ALDH1A1MAPTKDM4EHPGDLMNA | |
| SCHEMBL529871 | 0.76 | BCAT2 (0.48) | MKNK1MKNK2ALDH1A1MAPTKDM4E | |
| SCHEMBL4410163 | 0.76 | BCAT2 (0.42) | MKNK1MKNK2ALDH1A1MAPTKDM4E | |
| SCHEMBL2116017 | 0.75 | MKNK1 (0.45) | MKNK1MKNK2ALDH1A1MAPTKDM4E | |
| SCHEMBL5504646 | 0.75 | CYP3A4 (0.49) | MKNK1MKNK2ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | claimed |