Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | DHPS | P49366 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797972 | 0.86 | DHPS (0.47) | SMN1; SMN2RAB9AHTTNPC1HPGD | |
| SCHEMBL13359267 | 0.84 | NPC1 (0.49) | SMN1; SMN2RAB9AHTTNPC1MAPK1 | |
| SCHEMBL13359290 | 0.83 | DHPS (0.44) | RAB9AHTTNPC1HPGDALDH1A1 | |
| SCHEMBL13811161 | 0.81 | DHPS (0.43) | RAB9AHTTNPC1HPGDLMNA | |
| SCHEMBL13797936 | 0.78 | MAPK14 (0.68) | SMN1; SMN2RAB9AHTTNPC1MAPK1 | |
| SCHEMBL13359286 | 0.78 | MAPK14 (0.49) | SMN1; SMN2RAB9AHTTNPC1MAPK1 | |
| SCHEMBL13359266 | 0.78 | MAPK14 (0.59) | RAB9AHTTHPGDCASP3SENP8 | |
| SCHEMBL13359225 | 0.75 | HTT (0.52) | RAB9AHTTNPC1HPGDGAA | |
| SCHEMBL2893152 | 0.75 | ALDH1A1 (0.49) | SMN1; SMN2MAPK1HPGDALDH1A1LMNA | |
| SCHEMBL13797975 | 0.74 | MAPK14 (0.55) | SMN1; SMN2RAB9AHTTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |