Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.69 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.49 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.49 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29760376 | 0.84 | NAPRT (0.72) | NAPRTDGAT1RAB9ASMN1; SMN2KCNQ3 | |
| SCHEMBL7440808 | 0.84 | NAPRT (0.72) | NAPRTDGAT1RAB9ASMN1; SMN2KCNQ3 | |
| SCHEMBL17801 | 0.84 | NAPRT (0.72) | NAPRTDGAT1RAB9ASMN1; SMN2KCNQ3 | |
| SCHEMBL3748187 | 0.82 | NAPRT (0.69) | NAPRTDGAT1RAB9ASMN1; SMN2KCNQ3 | |
| Hydrochloric Acid SCHEMBL2928501 | 0.82 | NAPRT (0.69) | NAPRTDGAT1RAB9ASMN1; SMN2KCNQ3 | |
| 6-Chloronicotinic Acid SCHEMBL104580 | 0.82 | NAPRT (1.00) | NAPRTDGAT1RAB9ASMN1; SMN2KCNQ3 | |
| 6-Chloronicotinic Acid SCHEMBL29524158 | 0.82 | NAPRT (1.00) | NAPRTDGAT1RAB9ASMN1; SMN2KCNQ3 | |
| SCHEMBL2490628 | 0.80 | NAPRT (0.67) | NAPRTDGAT1RAB9ASMN1; SMN2KCNQ3 | |
| 6-Chloronicotinic Acid SCHEMBL10575126 | 0.80 | NAPRT (0.96) | NAPRTDGAT1RAB9ASMN1; SMN2KCNQ3 | |
| SCHEMBL10579409 | 0.80 | NAPRT (0.67) | NAPRTDGAT1RAB9ASMN1; SMN2KCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1921077-B1 | AGENT FOR TREATING AND/OR PREVENTING SLEEP DISORDER | KYOWA HAKKO KIRIN CO LTD (JP) | 2017-07-26 | — | — | EP | disclosed |
| US-8324385-B2 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | disclosed |
| US-20090197894-A1 | NICOTINAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, MOGAT2 | NAPRT 317/4885DGAT1 2/4885RAB9A 2586/4885 |
| US-20090197894-A1 | NICOTINAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | NAMPT, NNT, NNMT | NAPRT 15/4885DGAT1 2461/4885RAB9A 1717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.