Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 3/20 | 0.40 |
| ▸ | CTSB | P07858 | 3/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.39 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29351243 | 1.00 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNAPTGS2TDP1 | |
| SCHEMBL29789591 | 0.97 | CTSC (0.43) | ALDH1A1MAPTLMNAPTGS2TDP1 | |
| SCHEMBL29364551 | 0.95 | CTSC (0.42) | ALDH1A1MAPTLMNAPTGS2TDP1 | |
| SCHEMBL31111445 | 0.92 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNAPTGS2TDP1 | |
| SCHEMBL29692448 | 0.92 | REN (0.39) | ALDH1A1MAPTLMNAPTGS2TDP1 | |
| SCHEMBL29634121 | 0.91 | CTSC (0.41) | ALDH1A1MAPTLMNAPTGS2TDP1 | |
| SCHEMBL31589113 | 0.89 | FOLH1 (0.46) | CTSCPTGS1GSTK1GLO1 | |
| SCHEMBL11127918 | 0.88 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNACTSCCTSB | |
| SCHEMBL5176246 | 0.87 | CTSC (0.38) | ALDH1A1MAPTCTSCCTSLCTSB | |
| SCHEMBL30170441 | 0.87 | GLO1 (0.44) | CTSCPTGS1GSTK1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093867-A1 | Method Of Treating Genetic Disease Caused By Nonsense Mutation | THE UNIVERSITY OF TOKYO (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100093867-A1 | Method Of Treating Genetic Disease Caused By Nonsense Mutation | THE UNIVERSITY OF TOKYO (JP) | 2010-04-15 | — | — | US | disclosed |
| EP-2047848-A1 | METHOD OF TREATING GENETIC DISEASE CAUSED BY NONSENSE MUTATION | The University of Tokyo (JP) | 2009-04-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093867-A1 | Method Of Treating Genetic Disease Caused By Nonsense Mutation | UPF1, CLN6, PRPF6 | ALDH1A1 4267/4885MAPT 4043/4885LMNA 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.