Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.41 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14446344 | 0.81 | LOX (0.43) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL9616703 | 0.79 | LOX (0.41) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL2784650 | 0.76 | LMNA (0.40) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL9616973 | 0.76 | LOX (0.39) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL19829483 | 0.76 | LOX (0.39) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL8217266 | 0.72 | LOX (0.36) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL30834844 | 0.70 | POLB (0.35) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL13963799 | 0.70 | ALDH1A1 (0.40) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL12900984 | 0.70 | LMNA (0.50) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL11639145 | 0.70 | LMNA (0.55) | LMNAPTGS1ABCB11LOXLOXL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100076018-A1 | Compounds and Methods for Treatment of Alpha-1 Antitrypsin Deficiency | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100076018-A1 | Compounds and Methods for Treatment of Alpha-1 Antitrypsin Deficiency | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076018-A1 | Compounds and Methods for Treatment of Alpha-1 Antitrypsin Deficiency | SERPINA2, SERPINB1, SERPINC1 | LMNA 1085/4885PTGS1 610/4885ABCB11 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.