Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.83 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.83 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.69 |
| ▸ | CNR2 | P34972 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25873193 | 0.93 | PTGS2 (0.80) | AKR1C3AKR1C2PTGS2CNR2MAPT | |
| SCHEMBL27768669 | 0.92 | AKR1C3 (0.78) | AKR1C3AKR1C2PTGS2CNR2MAPT | |
| SCHEMBL16656482 | 0.91 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2CNR2MAPT | |
| SCHEMBL17946351 | 0.86 | AKR1C3 (0.78) | AKR1C3AKR1C2PTGS2MAPTLMNA | |
| SCHEMBL20346374 | 0.83 | PTGS2 (0.64) | AKR1C3AKR1C2PTGS2CNR2HIF1A | |
| SCHEMBL14983579 | 0.82 | AKR1C3 (0.60) | AKR1C3AKR1C2PTGS2MAPTLMNA | |
| SCHEMBL20346373 | 0.82 | PTGS2 (0.79) | AKR1C3PTGS2CNR2HIF1A | |
| SCHEMBL20259423 | 0.82 | PTGS2 (0.78) | AKR1C3AKR1C2PTGS2CNR2MAPT | |
| SCHEMBL24890591 | 0.82 | AKR1C3 (0.64) | AKR1C3AKR1C2PTGS2CNR2MAPT | |
| SCHEMBL30761037 | 0.82 | AKR1C3 (0.87) | AKR1C3AKR1C2PTGS2CNR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012647-B2 | Nitroxide modified non-steroidal anti-inflammatory compounds and uses thereof in the treatment and prevention of diseases or disorders | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-04-21 | — | — | US | disclosed |
| US-20120263650-A1 | NITROXIDE MODIFIED NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF IN THE TREATMENT AND PREVENTION OF DISEASES OR DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH | 2012-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120263650-A1 | NITROXIDE MODIFIED NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF IN THE TREATMENT AND PREVENTION OF DISEASES OR DISORDERS | NOS1, NOS3, PTGS1 | AKR1C3 315/4885AKR1C2 415/4885PTGS2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.