Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1344851 | 0.86 | EPHX2 (0.53) | LDHAEPHX2ALDH1A1KDM4EHTT | |
| SCHEMBL1346076 | 0.81 | TAS2R14 (0.46) | LDHAEPHX2TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL1344504 | 0.81 | EPHX2 (0.44) | LDHAEPHX2ALDH1A1KDM4EHTT | |
| SCHEMBL1346136 | 0.77 | EPHX2 (0.48) | LDHAEPHX2TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL1346468 | 0.76 | TAS1R3 (0.47) | LDHAEPHX2TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL10982437 | 0.76 | ESR1 (0.47) | EPHX2TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL1347512 | 0.72 | EPHX2 (0.51) | LDHAEPHX2ALDH1A1KDM4EHTT | |
| SCHEMBL9862619 | 0.72 | SHBG (0.40) | PDE2ATAS1R3TAS1R1HTTTAS2R14 | |
| SCHEMBL15668966 | 0.71 | HTT (0.51) | LDHATAS1R3TAS1R1ALDH1A1KDM4E | |
| SCHEMBL3235287 | 0.71 | LDHA (0.44) | LDHAALDH1A1KDM4EMITFHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406206-B1 | TETRAHYDRONAPHTHALEN-2-OL DERIVATIVES | MSD OSS BV (NL) | 2013-01-30 | — | — | EP | disclosed |
| EP-2406206-A1 | TETRAHYDRONAPHTHALEN-2-OL DERIVATIVES | MSD Oss B.V. (NL) | 2012-01-18 | — | — | EP | disclosed |
| US-8063102-B2 | Tetrahydronaphthalen-2-ol derivatives | N.V. ORGANON (NL) | 2011-11-22 | — | — | US | disclosed |
| US-20100240748-A1 | TETRAHYDRONAPHTHALEN-2-OL DERIVATIVES | N. V. ORGANON | 2010-09-23 | — | — | US | disclosed |
| WO-2010103095-A1 | TETRAHYDRONAPHTHALEN-2-OL DERIVATIVES | N.V. ORGANON (NL) | 2010-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240748-A1 | TETRAHYDRONAPHTHALEN-2-OL DERIVATIVES | VHL, BRCA1, TPH2 | LDHA 995/4885EPHX2 1099/4885PDE2A 4093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.