Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12903289 | 0.84 | — | — | |
| SCHEMBL31479423 | 0.83 | CHRM2 (0.39) | CHRM2CHRM4CHRM5CHRM3ALDH1A1 | |
| SCHEMBL1512803 | 0.79 | CHRM2 (0.47) | CHRM2CHRM4CHRM5CHRM3ALDH1A1 | |
| SCHEMBL323060 | 0.76 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM3ALDH1A1 | |
| SCHEMBL322281 | 0.76 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM3ALDH1A1 | |
| SCHEMBL323220 | 0.76 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM3ALDH1A1 | |
| SCHEMBL189762 | 0.76 | LMNA (0.44) | ALDH1A1L3MBTL1SMN1; SMN2NPC1LMNA | |
| SCHEMBL27419581 | 0.76 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM3ALDH1A1 | |
| SCHEMBL1965496 | 0.75 | ALDH1A1 (0.44) | CHRM2CHRM4CHRM5CHRM3ALDH1A1 | |
| SCHEMBL9938587 | 0.75 | CHRM2 (0.42) | CHRM2CHRM4CHRM5CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193379-B2 | Method for preparing 4B-amino-4′-demethyl-4-desoxypodophyllotoxin | Medicament, Pierre Fabre (FR) | 2012-06-05 | — | — | US | claimed |
| US-8063214-B2 | Polymorphic forms of tadalafil | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-11-22 | — | — | US | claimed |
| WO-2023142985-A1 | PREPARATION METHOD FOR TGF-β-INHIBITING ANTI-TUMOR DRUG | 四川科伦博泰生物医药股份有限公司 | 2023-08-03 | — | — | WO | disclosed |
| US-20100075973-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-25 | — | — | US | disclosed |
| WO-2010025073-A1 | DIHYDROIMIDAZO [ 1, 5-F] PTERIDINES AS POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-04 | — | — | WO | disclosed |
| US-7312330-B2 | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2007-12-25 | — | — | US | disclosed |
| US-20060264623-A1 | DNA-PK inhibitors | KUDOS PHARMACEUTICALS LIMITED (GB) | 2006-11-23 | — | — | US | disclosed |
| WO-2006118598-A1 | BICYCLOHETEROARYLAMINE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF | RENOVIS, INC. (US) | 2006-11-09 | — | — | WO | disclosed |
| US-20050277643-A1 | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof | EVOTEC AG (DE) | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075973-A1 | POLO-LIKE KINASE INHIBITORS | PLK2, PLK4, PLK1 | CHRM2 4880/4885CHRM4 4873/4885CHRM5 4868/4885 |
| US-20060264623-A1 | DNA-PK inhibitors | TOP2B, TOP2A, POLN | CHRM2 4690/4885CHRM4 4737/4885CHRM5 4755/4885 |
| US-20050277643-A1 | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof | TRPV1, TRPV3, TRPA1 | CHRM2 451/4885CHRM4 321/4885CHRM5 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.