Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ME2 | P23368 | 8/20 | 0.46 |
| ▸ | ME1 | P48163 | 8/20 | 0.46 |
| ▸ | ME3 | Q16798 | 8/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7936728 | 0.88 | GPR119 (0.53) | MAPTGAALMNAALDH1A1TDP1 | |
| SCHEMBL381360 | 0.81 | MAPT (0.68) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL13279526 | 0.78 | MAPT (0.64) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL17550836 | 0.77 | TRPC6 (0.44) | MAPTLMNAALDH1A1GPR119 | |
| SCHEMBL9396856 | 0.77 | MAPT (0.62) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL13281422 | 0.77 | MAPT (0.62) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL13465510 | 0.76 | GAA (0.56) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL13279578 | 0.75 | MAPT (0.47) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL5573222 | 0.73 | MAPT (0.76) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL7041242 | 0.73 | MAPT (0.68) | MAPTKDM4EGAALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255100-B2 | Substituted imidazopyridazines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-09 | — | — | US | disclosed |