Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13488441 | 0.94 | CXCR3 (0.43) | ALDH1A1CXCR3MEN1KMT2AADORA1 | |
| SCHEMBL5727368 | 0.81 | CASP3 (0.49) | MEN1KMT2AADORA1SMN1; SMN2NPSR1 | |
| SCHEMBL20765935 | 0.81 | KMT2A (0.46) | ALDH1A1MEN1KMT2AADORA1TP53 | |
| SCHEMBL17629577 | 0.78 | MAPT (0.42) | ALDH1A1MEN1KMT2AADORA1MAPT | |
| SCHEMBL5731017 | 0.76 | CHRM5 (0.48) | ALDH1A1MEN1KMT2AADORA1TP53 | |
| SCHEMBL5927238 | 0.75 | ADORA1 (0.46) | ALDH1A1MEN1KMT2AADORA1MAPT | |
| SCHEMBL4318911 | 0.74 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AROCK2CHEK2 | |
| SCHEMBL13780301 | 0.74 | DPP4 (0.45) | ALDH1A1MEN1KMT2AROCK2CHEK2 | |
| SCHEMBL26647798 | 0.74 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AADORA1MAPT | |
| SCHEMBL3197591 | 0.73 | SLC6A3 (0.55) | ADORA1MAPTTP53POLBESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445481-B2 | Scaffold-diversified pyrrolidinone derivatives and their use | THE UNIVERSITY OF CHICAGO (US) | 2013-05-21 | — | — | US | disclosed |
| US-8445481-B2 | Scaffold-diversified pyrrolidinone derivatives and their use | THE UNIVERSITY OF CHICAGO (US) | 2013-05-21 | — | — | US | disclosed |
| US-20100035892-A1 | METHOD FOR ASSEMBLING HIGH-PURITY CHEMICAL LIBRARIES, COMPOUNDS SUPPRESSING ACETYL COENZYME A CARBOXYLASE ACTIVITIES DISCOVERED BY SAME | THE UNIVERSITY OF CHICAGO | 2010-02-11 | — | — | US | disclosed |
| US-20100035892-A1 | METHOD FOR ASSEMBLING HIGH-PURITY CHEMICAL LIBRARIES, COMPOUNDS SUPPRESSING ACETYL COENZYME A CARBOXYLASE ACTIVITIES DISCOVERED BY SAME | THE UNIVERSITY OF CHICAGO | 2010-02-11 | — | — | US | disclosed |
| WO-2008103382-A1 | METHOD FOR ASSEMBLING HIGH-PURITY CHEMICAL LIBRARIES, COMPOUNDS SUPPRESSING ACETYL COENZYME A CARBOXYLASE ACTIVITIES DISCOVERED BY SAME | KOZMIN SERGEY (US) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035892-A1 | METHOD FOR ASSEMBLING HIGH-PURITY CHEMICAL LIBRARIES, COMPOUNDS SUPPRESSING ACETYL COENZYME A CARBOXYLASE ACTIVITIES DISCOVERED BY SAME | ACACA, COASY, ACACB | ALDH1A1 219/4885CXCR3 2468/4885MEN1 3103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.