Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13490812 | 0.81 | PPARA (0.49) | SMN1; SMN2MAPK1ALDH1A1KDM4ETP53 | |
| SCHEMBL13490773 | 0.78 | KMT2A (0.45) | SMN1; SMN2POLBMAPK1ALDH1A1KDM4E | |
| SCHEMBL4487061 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBMAPK1RAB9ALMNA | |
| SCHEMBL791810 | 0.78 | LMNA (0.68) | SMN1; SMN2POLBMAPK1RAB9AALDH1A1 | |
| SCHEMBL13189262 | 0.77 | CALM1 (0.50) | MAPK1ALDH1A1 | |
| SCHEMBL4477658 | 0.77 | SMN1; SMN2 (0.63) | SMN1; SMN2MAPK1RAB9AALDH1A1KDM4E | |
| SCHEMBL88823 | 0.75 | ALDH1A1 (0.61) | POLBMAPK1ALDH1A1KMT2A | |
| SCHEMBL5393479 | 0.74 | LMNA (0.53) | SMN1; SMN2ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL12903697 | 0.72 | MAOB (0.47) | ALDH1A1 | |
| SCHEMBL13490816 | 0.72 | FFAR1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029647-A1 | 3,4,(5)-SUBSTITUTED TETRAHYDROPHYRIDINES | NOVARTIS AG (CH) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029647-A1 | 3,4,(5)-SUBSTITUTED TETRAHYDROPHYRIDINES | REN, PAH, ACE | SMN1; SMN2 2582/4885POLB 3495/4885MAPK1 2507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.