Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1351210 | 0.91 | DRD2 (0.44) | DRD2DRD4ALDH3A1TACR1MEN1 | |
| SCHEMBL1351009 | 0.77 | DRD3 (0.45) | DRD2DRD4ALDH3A1TACR1MAPK1 | |
| SCHEMBL24152329 | 0.76 | GSK3B (0.50) | DRD2TACR1SIGMAR1ALDH1A1 | |
| SCHEMBL1352544 | 0.76 | DRD2 (0.42) | DRD2DRD4ALDH3A1TACR1GAA | |
| SCHEMBL28980928 | 0.74 | DRD2 (0.43) | DRD2DRD4TACR1MAPK1MEN1 | |
| SCHEMBL1350774 | 0.72 | DRD2 (0.49) | DRD2DRD4TACR1MAPK1DRD3 | |
| SCHEMBL1348972 | 0.71 | HTR2C (0.50) | HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL30336973 | 0.70 | KMT2A (0.49) | DRD4MEN1KMT2ASIGMAR1ACHE | |
| SCHEMBL11447242 | 0.70 | ALDH1A1 (0.51) | DRD2DRD4GAAMAPK1MEN1 | |
| SCHEMBL22164729 | 0.70 | LMNA (0.34) | TACR1MAPK1KMT2ASIGMAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140163014-A1 | BENZODIAZEPINE AND PYRIDODIAZEPINE DERIVATIVES | ABBVIE INC. | 2014-06-12 | — | — | US | claimed |
| US-8673896-B2 | Benzodiazepine and pyridodiazepine derivatives | ABBVIE INC. (US) | 2014-03-18 | — | — | US | claimed |
| US-20110288069-A1 | Benzodiazepine and Pyridodiazepine Derivatives | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | US | claimed |
| US-20160052929-A1 | BENZODIAZEPINE AND PYRIDODIAZEPINE DERIVATIVES | ABBVIE INC. | 2016-02-25 | — | — | US | disclosed |
| US-9133206-B2 | Benzodiazepine and pyridodiazepine derivatives | ABBVIE INC. (US) | 2015-09-15 | — | — | US | disclosed |
| US-20140163014-A1 | BENZODIAZEPINE AND PYRIDODIAZEPINE DERIVATIVES | ABBVIE INC. | 2014-06-12 | — | — | US | disclosed |
| US-8673896-B2 | Benzodiazepine and pyridodiazepine derivatives | ABBVIE INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-20110288069-A1 | Benzodiazepine and Pyridodiazepine Derivatives | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288069-A1 | Benzodiazepine and Pyridodiazepine Derivatives | GABRA3, GABRB3, GABRA1 | DRD2 56/4885DRD4 112/4885ALDH3A1 1166/4885 |
| US-20160052929-A1 | BENZODIAZEPINE AND PYRIDODIAZEPINE DERIVATIVES | GABRA3, GABRB3, GABRA1 | DRD2 56/4885DRD4 112/4885ALDH3A1 1166/4885 |
| US-20140163014-A1 | BENZODIAZEPINE AND PYRIDODIAZEPINE DERIVATIVES | GABRA3, GABRB3, GABRA1 | DRD2 56/4885DRD4 112/4885ALDH3A1 1166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.