SCHEMBL135489

SCHEMBL135489

O=C(Cl)OCc1cccc2c1Cc1ccccc1-2

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNMT P11086 1/20 0.54
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
ALDH1A1 P00352 3/20 0.44
HTR7 P34969 2/20 0.42
HTR2B P41595 2/20 0.42
DRD2 P14416 4/20 0.40
DRD4 P21917 3/20 0.40
DRD3 P35462 3/20 0.40
HSP90AA1 P07900 1/20 0.37
MAPT P10636 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
GABRP O00591 1/20 0.36
GABRD O14764 1/20 0.36
GABRA1 P14867 1/20 0.36
GABRB1 P18505 1/20 0.36
GABRG2 P18507 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29848427 1.00 PNMT (0.54) PNMTNPC1RAB9AALDH1A1HTR7
SCHEMBL29368791 1.00 PNMT (0.54) PNMTNPC1RAB9AALDH1A1HTR7
Benzene SCHEMBL28021305 0.99 PNMT (0.53) PNMTNPC1RAB9AALDH1A1HTR7
Acetonitrile SCHEMBL28942670 0.92 PNMT (0.47) PNMTNPC1RAB9AALDH1A1HTR7
SCHEMBL28811896 0.91 PNMT (0.46) PNMTNPC1RAB9AALDH1A1HTR7
SCHEMBL27921405 0.89 PNMT (0.49) PNMTNPC1RAB9AALDH1A1HTR7
SCHEMBL7000069 0.89 PNMT (0.51) PNMTNPC1RAB9AALDH1A1HTR7
SCHEMBL1830397 0.88 PNMT (0.57) PNMTNPC1RAB9AALDH1A1HTR7
SCHEMBL1830400 0.87 PNMT (0.55) PNMTNPC1RAB9AALDH1A1HTR7
SCHEMBL8671794 0.87 PNMT (0.55) PNMTNPC1RAB9AALDH1A1HTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1757 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121570433-A Glutamine metabolism regulation nano drug delivery system for enhancing pancreatic cancer targeting and penetration, and preparation method and application thereof 复旦大学 2026-02-27 CN claimed
US-20250270177-A1 PURIFICATION METHOD FOR ELECTRON MEDIATOR LEADWAY (HK) LIMITED (CN) 2025-08-28 US claimed
CN-120058715-A Intermediate of RHYNCHINES A compound and synthesis method thereof 河北科技大学 2025-05-30 CN claimed
CN-116730849-B Preparation method of optically active [1- (1-amino ethyl) cyclopropyl ] methanol 江苏艾迪药业股份有限公司 2025-04-29 CN claimed
WO-2025083736-A1 NOVEL PROCESS FOR THE PREPARATION OF PIRTOBRUTINIB AND ITS INTERMEDIATES THEREOF MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) 2025-04-24 WO claimed
US-20250109415-A1 SUSTAINABLE FUNCTIONALIZATION AND METHODS OF USE THEREOF UNIV ARIZONA STATE (US) 2025-04-03 US claimed
CN-119264549-B Scratch-resistant PE composite board and preparation method thereof 上犹县穗联工程塑料厂(普通合伙) 2025-03-28 CN claimed
CN-116375789-B Antitumor compound, preparation method thereof, pharmaceutical composition and application 北京大学第一医院 2025-03-21 CN claimed
EP-4512802-A1 PURIFICATION METHOD FOR ELECTRON MEDIATOR Leadway (HK) Limited (CN) 2025-02-26 EP claimed
WO-2025007401-A1 CONSTRUCT FOR REAL-TIME TRACING OF SPATIAL GENOME CONFORMATION AND TRANSCRIPTION PRODUCTS IN LIVING CELLS AND USE THEREOF 生物岛实验室 2025-01-09 WO claimed
US-20040236104-A1 Substituted 4-aminocyclohexanols GRUENENTHAL GMBH (DE) 2004-11-25 US claimed
US-20040214822-A1 Substituted 4-aminocyclohexanol compounds GRUENENTHAL GMBH (DE) 2004-10-28 US claimed
EP-0589004-A1 PROCESS FOR THE DETERMINATION OF PEPTIDES CORRESPONDING TO IMMUNOLOGICALLY IMPORTANT EPITOPES AND THEIR USE IN A PROCESS FOR DETERMINATION OF ANTIBODIES OR BIOTINYLATED PEPTIDES CORRESPONDING TO IMMUNOLOGICALLY IMPORTANT EPITOPES, A PROCESS FOR PREPARING THEM AND COMPOSITIONS CONTAINING THEM N.V. INNOGENETICS S.A. (BE) 1994-03-30 EP claimed
WO-1993018054-A2 PROCESS FOR THE DETERMINATION OF PEPTIDES CORRESPONDING TO IMMUNOLOGICALLY IMPORTANT EPITOPES AND THEIR USE IN A PROCESS FOR DETERMINATION OF ANTIBODIES OR BIOTINYLATED PEPTIDES CORRESPONDING TO IMMUNOLOGICALLY IMPORTANT EPITOPES, A PROCESS FOR PREPARING THEM AND COMPOSITIONS CONTAINING THEM N.V. INNOGENETICS S.A. (BE) 1993-09-16 WO claimed
EP-0530252-A4 AMINOALKYLCARBAMYL DERIVATIVES OF FORSKOLIN AS INTERMEDIATES FOR THE SYNTHESIS OF USEFUL FORSKOLIN DERIVATIVES US HEALTH (US) 1993-09-01 EP claimed
EP-0530252-A1 AMINOALKYLCARBAMYL DERIVATIVES OF FORSKOLIN AS INTERMEDIATES FOR THE SYNTHESIS OF USEFUL FORSKOLIN DERIVATIVES THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE (US) 1993-03-10 EP claimed
EP-0277561-B1 NEW ARGININE DERIVATIVE, PROCESS FOR THE PREPARATION THEREOF AND ITS USE IN PEPTIDE SYNTHESIS ENIRICERCHE S.p.A. (IT) 1992-04-15 EP claimed
WO-1991017154-A1 AMINOALKYLCARBAMYL DERIVATIVES OF FORSKOLIN AS INTERMEDIATES FOR THE SYNTHESIS OF USEFUL FORSKOLIN DERIVATIVES THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE (US) 1991-11-14 WO claimed
EP-0233973-B1 MIXTURE OF AMINO ACID DERIVATIVES, PROCESS OF PRODUCING THE MIXTURE AND USE OF THE MIXTURE FOR QUANTITATIVE DETERMINATION OF THE AMINO ACIDS Hewlett-Packard GmbH (DE) 1990-12-27 EP claimed
EP-0277561-A1 New arginine derivative, process for the preparation thereof and its use in peptide synthesis ENIRICERCHE S.p.A. (IT) 1988-08-10 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040214822-A1 Substituted 4-aminocyclohexanol compounds ADRA2C, OPRD1, OPRK1 PNMT 254/4885NPC1 740/4885RAB9A 2326/4885
US-20250270177-A1 PURIFICATION METHOD FOR ELECTRON MEDIATOR MB, DAO, BCAT2 PNMT 78/4885NPC1 4354/4885RAB9A 3087/4885
US-20040236104-A1 Substituted 4-aminocyclohexanols CNR2, OPRK1, OPRL1 PNMT 270/4885NPC1 1020/4885RAB9A 3382/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.