Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13554248 | 0.82 | ENPP2 (0.31) | ENPP2 | |
| SCHEMBL2850890 | 0.80 | HTT (0.45) | ENPP2LPLLIPGHTT | |
| SCHEMBL13554240 | 0.78 | RXRA (0.35) | ENPP2 | |
| SCHEMBL14217725 | 0.76 | REN (0.38) | ENPP2CA1CA2 | |
| SCHEMBL13554244 | 0.76 | SLC6A4 (0.33) | HTT | |
| SCHEMBL22471 | 0.74 | ENPP2 (0.47) | ENPP2CA1CA2HTT | |
| SCHEMBL29427154 | 0.74 | ENPP2 (0.47) | ENPP2CA1CA2HTT | |
| SCHEMBL11894322 | 0.74 | ALDH1A1 (0.41) | HTT | |
| SCHEMBL12100513 | 0.73 | CA2 (0.50) | ENPP2CA1CA2LPLLIPG | |
| SCHEMBL26978166 | 0.73 | MGLL (0.33) | ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120270838-A1 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270838-A1 | SPIROIMIDAZOLONE DERIVATIVE | WNK3, REN, SGK3 | ENPP2 4417/4885CA1 3253/4885CA2 921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.