Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771748 | 0.86 | HSD17B1 (0.46) | ALDH1A1KMT2ATSHRMEN1HSD17B1 | |
| SCHEMBL2900503 | 0.83 | KDM4E (0.48) | ALDH1A1KMT2ATSHRMEN1KDM4E | |
| SCHEMBL3269177 | 0.82 | CYP1A2 (0.52) | ALDH1A1KMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL2899236 | 0.82 | HTT (0.55) | ALDH1A1KMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL2902879 | 0.82 | HTT (0.46) | ALDH1A1KMT2ATSHRKDM4EMAPT | |
| SCHEMBL28089256 | 0.82 | POLB (0.35) | ALDH1A1KMT2ATSHRMEN1SMN1; SMN2 | |
| SCHEMBL2902630 | 0.81 | KMT2A (0.58) | ALDH1A1KMT2ATSHRMEN1SMN1; SMN2 | |
| SCHEMBL2894992 | 0.80 | SMN1; SMN2 (0.48) | ALDH1A1KMT2AKDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL2901269 | 0.80 | SMN1; SMN2 (0.48) | ALDH1A1KMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL2900768 | 0.80 | LMNA (0.49) | ALDH1A1MAPK1L3MBTL1HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | claimed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | claimed |
| EP-2108020-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | claimed |
| WO-2008094602-A2 | 1-H-PYRAZOLO (3,4B) PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | claimed |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | disclosed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | disclosed |
| EP-2108020-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | disclosed |
| WO-2008094602-A2 | 1-H-PYRAZOLO (3,4B) PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | disclosed |
| US-20080108576-A1 | Novel cytostatic conjugates with integrin ligands | BAYER AKTIENGESELLSCHAFT (DE) | 2008-05-08 | — | — | US | disclosed |
| US-7304037-B2 | Cytostatic conjugates with integrin ligands | BAYER AKIENGESELLSCHAFT (DE) | 2007-12-04 | — | — | US | disclosed |
| US-20020193311-A1 | Novel cytostatic conjugates with integrin ligands | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2002-12-19 | — | — | US | disclosed |
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| EP-0436938-A2 | Silver halide color photographic material containing yellow colored cyan coupler | Fuji Photo Film Co., Ltd. (JP) | 1991-07-17 | — | — | EP | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |
| EP-0377463-A2 | Silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1990-07-11 | — | — | EP | disclosed |
| EP-0376212-A2 | Silver halide color photographic photosensitive materials | FUJI PHOTO FILM CO., LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |
| EP-0369486-A2 | Negative type silver halide color photographic lightsensitive material | Fuji Photo Film Co., Ltd. (JP) | 1990-05-23 | — | — | EP | disclosed |
| EP-0310125-A2 | Silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1989-04-05 | — | — | EP | disclosed |
| EP-0296606-A2 | Silver halide color photographic materials and processing method | FUJI PHOTO FILM CO., LTD. (JP) | 1988-12-28 | — | — | EP | disclosed |
| EP-0237695-A2 | 1,4-Dihydropyridines | MERCK PATENT GmbH (DE) | 1987-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193311-A1 | Novel cytostatic conjugates with integrin ligands | ITGB3, ITGAV, ITGB5 | ALDH1A1 2365/4885KMT2A 3876/4885TSHR 1906/4885 |
| US-20080108576-A1 | Novel cytostatic conjugates with integrin ligands | ITGB3, ITGAV, ITGB5 | ALDH1A1 1921/4885KMT2A 4000/4885TSHR 1682/4885 |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | ALDH1A1 4063/4885KMT2A 1137/4885TSHR 4502/4885 |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | ALDH1A1 4063/4885KMT2A 1137/4885TSHR 4502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.