Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ENPP3 | O14638 | 9/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 8/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565970 | 0.89 | ALDH1A1 (0.50) | LMNASMN1; SMN2HTTNPSR1HPGD | |
| SCHEMBL10115276 | 0.88 | LMNA (0.52) | LMNAENPP3ENPP1ENPP2PTPN1 | |
| SCHEMBL13565532 | 0.84 | ENPP3 (0.50) | LMNAENPP3ENPP1ENPP2PTPN1 | |
| SCHEMBL29220635 | 0.82 | NAAA (0.58) | LMNAENPP3ENPP1ENPP2PTPN1 | |
| SCHEMBL13565647 | 0.81 | LMNA (0.42) | LMNASMN1; SMN2HTTRAB9AKMT2A | |
| SCHEMBL11935679 | 0.81 | KMT2A (0.51) | LMNASMN1; SMN2RAB9AHPGDKMT2A | |
| SCHEMBL13564778 | 0.80 | POLB (0.49) | LMNASMN1; SMN2HTTNPSR1HPGD | |
| SCHEMBL10115271 | 0.80 | ALDH1A1 (0.49) | LMNASMN1; SMN2NPSR1HPGDMEN1 | |
| SCHEMBL11935698 | 0.79 | PTPN1 (0.57) | LMNAENPP3ENPP1ENPP2PTPN1 | |
| SCHEMBL13565527 | 0.78 | CTSL (0.38) | LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |