Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10799503 | 0.80 | MAPT (0.55) | ALOX5KMT2AMAPTMEN1THRB | |
| SCHEMBL9041388 | 0.78 | MAPT (0.57) | ALOX5HSP90AB1KMT2AMAPTMEN1 | |
| SCHEMBL10713704 | 0.77 | ALDH1A1 (0.60) | ALOX5HSP90AB1KMT2AMAPTMEN1 | |
| SCHEMBL11989292 | 0.77 | CASP1 (0.45) | ALOX5HSP90AB1KMT2AMAPTMEN1 | |
| SCHEMBL21123646 | 0.76 | GAA (0.57) | ALOX5KMT2AMAPTMEN1KDM4E | |
| SCHEMBL270136 | 0.76 | GABRA1 (0.45) | HSP90AB1KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL27574494 | 0.75 | P2RX7 (0.43) | HSP90AB1KMT2AMAPTMEN1THRB | |
| SCHEMBL27944283 | 0.75 | HSP90AB1 (0.42) | ALOX5HSP90AB1KMT2AMAPTMEN1 | |
| SCHEMBL9559750 | 0.74 | HSP90AB1 (0.48) | HSP90AB1KMT2AMAPTMEN1THRB | |
| SCHEMBL6566640 | 0.73 | ALDH1A1 (0.58) | ALOX5MAPTKDM4EALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155042-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-23 | — | — | WO | disclosed |