Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28629659 | 0.80 | — | — | |
| SCHEMBL27701241 | 0.68 | MAPT (0.41) | KDM4ELMNAMAPTTP53POLB | |
| SCHEMBL17171677 | 0.65 | KDM4E (0.39) | KDM4EALDH1A1LMNAMAPTUSP2 | |
| SCHEMBL10498542 | 0.64 | LMNA (0.70) | KDM4EALDH1A1LMNAMAPTUSP2 | |
| SCHEMBL6663539 | 0.64 | — | — | |
| SCHEMBL4072362 | 0.64 | KDM4E (0.47) | KDM4EALDH1A1LMNAMAPTUSP2 | |
| SCHEMBL981646 | 0.63 | GAA (0.43) | KDM4EALDH1A1LMNAMAPTTP53 | |
| SCHEMBL14100657 | 0.62 | KDM4E (0.56) | KDM4EALDH1A1LMNAMAPTUSP2 | |
| SCHEMBL1267349 | 0.62 | KDM4E (0.56) | KDM4EALDH1A1LMNAMAPTUSP2 | |
| Benzene SCHEMBL9846947 | 0.61 | ALDH1A1 (0.33) | KDM4EALDH1A1MAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2527341-B1 | Process for preparation of pyrimidinylpyrazole compounds | SHISEIDO CO LTD (JP) | 2014-06-18 | — | — | EP | disclosed |
| US-8592582-B2 | Method for producing pyrimidinylpyrazole compounds | SHISEIDO COMPANY, LTD. (JP) | 2013-11-26 | — | — | US | disclosed |
| US-20120283441-A1 | Method For Producing Pyrimidinylpyrazole Compounds | SHISEIDO COMPANY, LTD. (JP) | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283441-A1 | Method For Producing Pyrimidinylpyrazole Compounds | DCK, IFNG, QDPR | KDM4E 1907/4885ALDH1A1 926/4885LMNA 4623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.