Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 15/20 | 0.44 |
| ▸ | NPC1 | O15118 | 13/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.41 |
| ▸ | HPGD | P15428 | 7/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9454334 | 0.69 | ALDH1A1 (0.44) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL13762461 | 0.69 | KDM4E (0.70) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL795461 | 0.67 | NPC1 (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL733957 | 0.67 | ALDH1A1 (0.49) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL262283 | 0.67 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL3475309 | 0.65 | TP53 (0.46) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL9454056 | 0.65 | RAB9A (0.41) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL3619389 | 0.65 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL1173378 | 0.65 | TDO2 (0.40) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL10626253 | 0.65 | ALDH1A1 (0.69) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165327-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | COSTANZO MICHAEL J (US) | 2012-06-28 | — | — | US | claimed |
| US-8158792-B2 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-04-17 | — | — | US | claimed |
| EP-2224803-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2010-09-08 | — | — | EP | claimed |
| US-20090163527-A1 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2009-06-25 | — | — | US | claimed |
| WO-2009067202-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-05-28 | — | — | WO | claimed |
| EP-1885709-A2 | BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES | Pharmos Corporation (US) | 2008-02-13 | — | — | EP | claimed |
| WO-2006129318-A2 | BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES | PHARMOS CORPORATION (US) | 2006-12-07 | — | — | WO | claimed |
| US-20210139453-A1 | (HETERO)ARYL SULFONAMIDE COMPOUND AND FORMULATION FOR CONTROLLING HARMFUL ORGANISMS | NIPPON SODA CO., LTD. (JP) | 2021-05-13 | — | — | US | disclosed |
| EP-3778574-A1 | (HETERO)ARYLSULFONAMIDE COMPOUND AND PEST CONTROL AGENT | Nippon Soda Co., Ltd. (JP) | 2021-02-17 | — | — | EP | disclosed |
| US-8536189-B2 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2013-09-17 | — | — | US | disclosed |
| US-8309579-B2 | N-hydroxyamide derivatives and use thereof | MERCK SERONO SA (CH) | 2012-11-13 | — | — | US | disclosed |
| US-8247437-B2 | N-hydroxyamide derivatives and use thereof | MERCK SERONO SA (CH) | 2012-08-21 | — | — | US | disclosed |
| US-20120165327-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | COSTANZO MICHAEL J (US) | 2012-06-28 | — | — | US | disclosed |
| EP-1771421-B1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | SERONO LAB (CH) | 2009-04-29 | — | — | EP | disclosed |
| US-20080275060-A1 | N-Hydroxyamide Derivatives and Use Thereof | LABORATOIRES SERONO SA (CH) | 2008-11-06 | — | — | US | disclosed |
| EP-1951687-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | Laboratoires Serono SA (CH) | 2008-08-06 | — | — | EP | disclosed |
| US-20080021028-A1 | N-Hydroxyamide Derivatives and Use Thereof | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2008-01-24 | — | — | US | disclosed |
| WO-2007060132-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2007-05-31 | — | — | WO | disclosed |
| EP-1771421-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006010751-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165327-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | TPSAB1, TPSB2, TPSD1 | RAB9A 2884/4885NPC1 1407/4885SMN1; SMN2 4323/4885 |
| US-20090163527-A1 | Spiropiperidines for use as tryptase inhibitors | TPSAB1, TPSB2, TPSD1 | RAB9A 2884/4885NPC1 1407/4885SMN1; SMN2 4323/4885 |
| US-20080021028-A1 | N-Hydroxyamide Derivatives and Use Thereof | HCAR2, HNMT, HPGD | RAB9A 2780/4885NPC1 655/4885SMN1; SMN2 1306/4885 |
| US-20080275060-A1 | N-Hydroxyamide Derivatives and Use Thereof | HNMT, HCAR2, HPGD | RAB9A 2765/4885NPC1 641/4885SMN1; SMN2 1322/4885 |
| US-20210139453-A1 | (HETERO)ARYL SULFONAMIDE COMPOUND AND FORMULATION FOR CONTROLLING HARMFUL ORGANISMS | ARSA, NAT1, SUB1 | RAB9A 504/4885NPC1 1340/4885SMN1; SMN2 3093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.