Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28677940 | 0.90 | KDM4E (0.42) | KDM4EMAPTGABRPGABRDGABRA1 | |
| SCHEMBL25845608 | 0.80 | GABRP (0.43) | MAPTGABRPGABRDGABRA1TSHR | |
| Ethyl Isonipecotate SCHEMBL6439825 | 0.80 | MAPT (0.51) | MAPTGABRPGABRDGABRA1TSHR | |
| Ethyl Isonipecotate SCHEMBL27886 | 0.80 | MAPT (0.51) | MAPTGABRPGABRDGABRA1TSHR | |
| Ethyl Isonipecotate SCHEMBL1420351 | 0.78 | MAPT (0.50) | MAPTGABRPGABRDGABRA1TSHR | |
| SCHEMBL18625010 | 0.78 | GABRA5 (0.50) | MAPTGABRPGABRDGABRA1TSHR | |
| SCHEMBL13601795 | 0.78 | MAPT (0.54) | KDM4EMAPTALDH1A1 | |
| SCHEMBL28598650 | 0.77 | GABRP (0.41) | MAPTGABRPGABRDGABRA1TSHR | |
| SCHEMBL9654364 | 0.77 | PLG (0.46) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9654358 | 0.77 | PLG (0.46) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |