Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ECE1 | P42892 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27830217 | 0.79 | TLR7 (0.50) | TLR7KDM4EHIF1ASMN1; SMN2ECE1 | |
| SCHEMBL23896444 | 0.78 | BTK (0.33) | KDM4ESMN1; SMN2ALDH1A1HPGDRAB9A | |
| SCHEMBL19240720 | 0.78 | L3MBTL1 (0.33) | KDM4ESMN1; SMN2ALDH1A1RAB9AGAA | |
| SCHEMBL15745603 | 0.78 | ALDH1A1 (0.51) | KDM4ESMN1; SMN2ALDH1A1RAB9AGAA | |
| SCHEMBL2643511 | 0.77 | — | — | |
| SCHEMBL457097 | 0.77 | — | — | |
| SCHEMBL12370920 | 0.76 | TLR7 (0.53) | TLR7KDM4EHIF1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16355745 | 0.76 | HPGDS (0.50) | TLR7KDM4EHIF1AECE1ALDH1A1 | |
| SCHEMBL18307620 | 0.76 | TLR7 (0.49) | TLR7SMN1; SMN2GAAMAPT | |
| SCHEMBL16908078 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12016896-B2 | Dipeptidomimetics as inhibitors of human immunoproteasomes | CORNELL UNIVERSITY (US) | 2024-06-25 | — | — | US | disclosed |
| US-20230365541-A1 | INHIBITOR OF ENHANCER OF ZESTE HOMOLOGUE 2, AND USE THEREOF | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2023-11-16 | — | — | US | disclosed |
| US-11202817-B2 | Dipeptidomimetics as inhibitors of human immunoproteasomes | CORNELL UNIVERSITY (US) | 2021-12-21 | — | — | US | disclosed |
| US-20200385371-A1 | INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING | Propellon Therapeutics Inc. (CA) | 2020-12-10 | — | — | US | disclosed |
| WO-2019233456-A1 | ERK INHIBITOR AND USE THEREOF | 贝达药业股份有限公司 (CN) | 2019-12-12 | — | — | WO | disclosed |
| US-20180221431-A1 | DIPEPTIDOMIMETICS AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-08-09 | — | — | US | disclosed |
| US-20180221431-A1 | DIPEPTIDOMIMETICS AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-08-09 | — | — | US | disclosed |
| US-9988421-B2 | Dipeptides as inhibitors of human immunoproteasomes | CORNELL UNIVERSITY (US) | 2018-06-05 | — | — | US | disclosed |
| US-9988421-B2 | Dipeptides as inhibitors of human immunoproteasomes | CORNELL UNIVERSITY (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170233411-A1 | THIAZOLYL-CONTAINING COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-08-17 | — | — | US | disclosed |
| US-20170121366-A1 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | CORNELL UNIVERSITY | 2017-05-04 | — | — | US | disclosed |
| US-20170121366-A1 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | CORNELL UNIVERSITY | 2017-05-04 | — | — | US | disclosed |
| US-20090280106-A1 | Pituitary adenylate cyclase acivating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use | BAYER PHARMACEUTICALS CORPORATION (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090137601-A1 | L-Phenylalanine Derivatives | ASTRAZENECA AB (SE) | 2009-05-28 | — | — | US | disclosed |
| US-20090137601-A1 | L-Phenylalanine Derivatives | ASTRAZENECA AB (SE) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233411-A1 | THIAZOLYL-CONTAINING COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES | BTK, BCL9L, BCL9 | TLR7 2458/4885KDM4E 3044/4885HIF1A 4775/4885 |
| US-20200385371-A1 | INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING | WDR5, WDR82, WDR1 | TLR7 4773/4885KDM4E 967/4885HIF1A 2278/4885 |
| US-20090280106-A1 | Pituitary adenylate cyclase acivating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use | ADCYAP1R1, VIPR2, ADCY2 | TLR7 2297/4885KDM4E 2974/4885HIF1A 1719/4885 |
| US-20170121366-A1 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | DNPEP, PSMB10, DPEP1 | TLR7 2353/4885KDM4E 809/4885HIF1A 3764/4885 |
| US-20180221431-A1 | DIPEPTIDOMIMETICS AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | PREP, CTSC, DNPEP | TLR7 1566/4885KDM4E 825/4885HIF1A 2646/4885 |
| US-20230365541-A1 | INHIBITOR OF ENHANCER OF ZESTE HOMOLOGUE 2, AND USE THEREOF | EZH2, BMI1, EZH1 | TLR7 3582/4885KDM4E 22/4885HIF1A 1648/4885 |
| US-11202817-B2 | Dipeptidomimetics as inhibitors of human immunoproteasomes | PREP, CTSC, DNPEP | TLR7 1529/4885KDM4E 841/4885HIF1A 2604/4885 |
| US-20090137601-A1 | L-Phenylalanine Derivatives | ITGB5, ITGB1, ITGA2B | TLR7 3546/4885KDM4E 2743/4885HIF1A 1171/4885 |
| US-12016896-B2 | Dipeptidomimetics as inhibitors of human immunoproteasomes | PREP, CTSC, DNPEP | TLR7 1529/4885KDM4E 841/4885HIF1A 2604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.