Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.32 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13611879 | 1.00 | DPP4 (0.48) | DPP4DPP8DPP9CHRNB1CHRNB2 | |
| SCHEMBL13612016 | 0.84 | DPP4 (0.44) | DPP4DPP8DPP9KMT2AMEN1 | |
| SCHEMBL13612014 | 0.79 | MAPT (0.40) | DPP4DPP8DPP9KMT2AMEN1 | |
| SCHEMBL13611869 | 0.79 | DPP4 (0.36) | DPP4DPP8DPP9 | |
| SCHEMBL13612018 | 0.76 | DPP4 (0.50) | DPP4DPP8DPP9SMO | |
| SCHEMBL13611902 | 0.75 | DPP4 (0.46) | DPP4DPP8DPP9SMO | |
| SCHEMBL13612023 | 0.74 | ALDH1A1 (0.38) | DPP4DPP8DPP9KMT2AMEN1 | |
| SCHEMBL13612028 | 0.74 | MEN1 (0.36) | DPP4DPP8CHRM3KMT2AMEN1 | |
| SCHEMBL13612049 | 0.73 | ANO1 (0.40) | DPP4DPP8DPP9SMODRD2 | |
| SCHEMBL13612035 | 0.73 | MAPT (0.41) | DPP4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635699-B2 | Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-22 | — | — | US | disclosed |