Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 4/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13612023 | 0.91 | ALDH1A1 (0.38) | MEN1KMT2ADPP4DPP8ALDH1A1 | |
| SCHEMBL13611767 | 0.84 | TDP1 (0.38) | DPP4DPP8ALDH1A1EPHX2 | |
| SCHEMBL13612035 | 0.83 | MAPT (0.41) | MEN1POLBKMT2ADPP4MAPT | |
| SCHEMBL13612049 | 0.82 | ANO1 (0.40) | MEN1KMT2ADPP4DPP8ALDH1A1 | |
| SCHEMBL13611902 | 0.82 | DPP4 (0.46) | DPP4DPP8EPHX2 | |
| SCHEMBL13612014 | 0.81 | MAPT (0.40) | MEN1POLBKMT2ADPP4DPP8 | |
| SCHEMBL13612016 | 0.81 | DPP4 (0.44) | MEN1KMT2ADPP4DPP8 | |
| SCHEMBL13612038 | 0.79 | KMT2A (0.41) | MEN1POLBKMT2ADPP4ALDH1A1 | |
| SCHEMBL13612007 | 0.78 | DPP4 (0.35) | DPP4DPP8 | |
| SCHEMBL13611869 | 0.77 | DPP4 (0.36) | DPP4DPP8MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635699-B2 | Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-22 | — | — | US | disclosed |