Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13613342 | 0.71 | CES2 (0.34) | PARP1GRM1MEN1KMT2ACYP1A2 | |
| SCHEMBL12333480 | 0.66 | TSHR (0.66) | TSHRCYP3A4MEN1KMT2ATDP1 | |
| SCHEMBL3829455 | 0.66 | TSHR (0.46) | TSHRCYP3A4MEN1KMT2ATDP1 | |
| SCHEMBL18610351 | 0.66 | TSHR (0.41) | TSHRCYP3A4CYP1A2LMNA | |
| SCHEMBL16750532 | 0.65 | ALOX5 (0.50) | LMNAALDH1A1 | |
| SCHEMBL987111 | 0.65 | ALOX5 (0.50) | LMNAALDH1A1 | |
| SCHEMBL8367112 | 0.65 | TSHR (0.48) | TSHRCYP3A4MEN1KMT2ATDP1 | |
| SCHEMBL14236331 | 0.64 | MAPT (0.31) | TSHRCYP3A4LMNAALDH1A1MAPT | |
| SCHEMBL12516797 | 0.63 | LMNA (0.40) | PARP1MEN1KMT2ATDP1LMNA | |
| SCHEMBL18708433 | 0.63 | ACHE (0.52) | TSHRCYP3A4MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119703-A1 | NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON I B KINASE | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-18 | — | — | EP | disclosed |