Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | LIG1 | P18858 | 1/20 | 0.37 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.34 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.34 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13614998 | 0.78 | HSD17B10 (0.36) | LMNAHSD17B10MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL2573400 | 0.76 | HSD17B10 (0.48) | LMNACYP3A4ADRA2BMAPK1HSD17B10 | |
| SCHEMBL11090264 | 0.72 | ALDH1A1 (0.49) | LMNAADRA2CHSD17B10MAPTL3MBTL1 | |
| SCHEMBL26118236 | 0.69 | TSHR (0.53) | LMNACYP3A4CYP2A6TSHRADRA2A | |
| Probenazol SCHEMBL23516 | 0.68 | PKM (0.65) | LMNAHPGDHSD17B10MAPTL3MBTL1 | |
| Probenazol SCHEMBL30425932 | 0.68 | PKM (0.65) | LMNAHPGDHSD17B10MAPTL3MBTL1 | |
| Probenazol SCHEMBL8409812 | 0.68 | PKM (0.65) | LMNAHPGDHSD17B10MAPTL3MBTL1 | |
| SCHEMBL11090288 | 0.67 | BACE1 (0.36) | LMNAALDH1A1 | |
| SCHEMBL2564355 | 0.67 | RET (0.43) | LMNATSHRALDH1A1 | |
| SCHEMBL5919579 | 0.66 | KCNA3 (0.50) | CYP3A4CYP2A6TSHRADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141065-A2 | (1,2-BENZISOTHIAZOL-3-YL)(THIO)CARBAMATES AND (1,2-BENZISOTHIAZOL-3-YL)(THIO)OXAMATES AND THE OXIDATION FORMS THEREOF FOR USE AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2009-11-26 | — | — | WO | disclosed |
| EP-2123159-A1 | (1,2-Benzisothiazol-3-yl)(thio)carbamates and (1,2-Benzisothiazol-3-yl)(thio)oxamates and their oxidation forms as pesticides | Bayer CropScience AG (DE) | 2009-11-25 | — | — | EP | disclosed |