Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | SIK1 | P57059 | 1/20 | 0.37 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | DSTYK | Q6XUX3 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616861 | 0.87 | PIM1 (0.40) | GRM2SRCPDGFRBCYP2A6BACE1 | |
| SCHEMBL13616805 | 0.76 | MPL (0.47) | BACE1KDM4EMPLALOX5APFEN1 | |
| SCHEMBL13616873 | 0.72 | CLK1 (0.37) | KDM4EMEN1KMT2A | |
| SCHEMBL13616971 | 0.70 | MPL (0.38) | KDM4EMPL | |
| SCHEMBL5544666 | 0.70 | NPC1 (0.39) | RIPK2ESR1ESR2MEN1KMT2A | |
| SCHEMBL13616808 | 0.70 | ALDH1A1 (0.46) | FLT3SRCPDGFRBKDRMEN1 | |
| SCHEMBL13520606 | 0.70 | GRM2 (0.44) | GRM2CYP2A6ESR1ESR2MEN1 | |
| SCHEMBL13616946 | 0.69 | ADORA2A (0.40) | SRCCYP2A6BACE1KDRKDM4E | |
| SCHEMBL1689568 | 0.69 | MPL (0.63) | KDM4EMEN1KMT2AMPLALOX5AP | |
| SCHEMBL25592271 | 0.68 | NSD2 (0.41) | CYP2A6HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |