Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616971 | 0.86 | MPL (0.38) | MPLALDH1A1KDM4EADORA2AMAP4K4 | |
| SCHEMBL2092932 | 0.78 | MPL (0.40) | MPLALDH1A1KDM4EADORA2AMAPK14 | |
| SCHEMBL13616946 | 0.78 | ADORA2A (0.40) | ALDH1A1KDM4EADORA2ADPP4MAPK14 | |
| SCHEMBL13617343 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAP4K4DPP4NPC1 | |
| SCHEMBL2092935 | 0.78 | MPL (0.40) | MPLALDH1A1KDM4EMAPK14NPC1 | |
| SCHEMBL13616873 | 0.77 | CLK1 (0.37) | ALDH1A1KDM4EMAP4K4DPP4 | |
| SCHEMBL13617070 | 0.76 | GRM2 (0.37) | MPLKDM4EALOX5APFEN1BACE1 | |
| SCHEMBL13616783 | 0.72 | KDM4E (0.53) | ALDH1A1KDM4EADORA2AMAP4K4MAPK14 | |
| SCHEMBL15692562 | 0.69 | KDM4E (0.50) | ALDH1A1KDM4ETGFBR1NPC1MAPK1 | |
| SCHEMBL983271 | 0.68 | KDM4E (0.42) | ALDH1A1KDM4ENPC1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |