Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616805 | 0.86 | MPL (0.47) | MPLKDM4EALDH1A1MAP4K4ADORA2A | |
| SCHEMBL13398609 | 0.74 | KDM4E (0.55) | KDM4ECNR2CYP1A2CYP3A4THPO | |
| SCHEMBL13616946 | 0.71 | ADORA2A (0.40) | KDM4EALDH1A1ADORA2ASMN1; SMN2CYP1A2 | |
| SCHEMBL13617343 | 0.71 | ALDH1A1 (0.43) | KDM4EALDH1A1MAP4K4SMN1; SMN2JAK2 | |
| SCHEMBL13616873 | 0.71 | CLK1 (0.37) | LRRK2KDM4EALDH1A1MAP4K4CYP3A4 | |
| SCHEMBL13617070 | 0.70 | GRM2 (0.37) | MPLKDM4E | |
| SCHEMBL13616861 | 0.70 | PIM1 (0.40) | MPLKDM4ESMN1; SMN2 | |
| SCHEMBL20570873 | 0.68 | PTPN11 (0.45) | MPLLRRK2BCAT1PTPN11KDM4E | |
| SCHEMBL3038641 | 0.67 | CES2 (0.46) | MPLBCAT1CNR2CCNE2CCNE1 | |
| SCHEMBL474677 | 0.67 | MPL (0.74) | MPLKDM4EALDH1A1SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |